摘要
消化道良性狭窄在临床上比较常见,现多采用内镜治疗联合药物治疗,但经治疗后狭窄容易复发,严重影响患者生活质量。治疗方法层出不穷、各有利弊。球囊扩张虽是比较安全的,但仍难以避免穿孔的发生,且对某些正常腔道部位的狭窄存在风险,需要充分的术前评估。支架可以持续扩张狭窄部位,但因食管与气管的位置毗邻,所以呼吸系统不成熟的早产儿不宜使用,目前缺乏与儿童年龄相符的支架。反复的内镜诊疗也给患者带来相应的风险和负担。组织工程的产物有与人体组织高度的相容性,不仅能预防狭窄,也能充当载体运输药物和细胞到狭窄处,但费时费力且代价昂贵。
Gastrointestinal benign stenosis is a clinically common disease,and endoscopic treatment combined with drug therapy is now widely applied,but after treatment,stenosis is easy to recur,and seriously affects the patients’ quality of life.Treatment methods have been emerging endlessly,each with own advantages and disadvantages.Although balloon dilatation is relatively safe,it is still difficult to avoid the occurrence of perforation,and there is a risk of stenosis in certain normal cavity sites,which requires sufficient preoperative evaluation.The stent can continue to expand the stenosis,but because the esophagus and the trachea are adjacent to each other,it’ s not suitable for the premature infants with immature respiratory system.There is still a lack of stent suitable for children.Repeated endoscopic diagnosis and treatment also bring corresponding risks and burden.The product of tissue engineering is highly compatible with human tissues,which can not only prevent stenosis,but also act as a carrier to transport drugs and cells to the stenosis,although it is time-consuming,laborious,and expensive.
作者
谢宇欣
郭键漪
姚欢
石国庆
XIE Yuxin;GUO Jianyi;YAO Huan;SHI Guoqing(Department of Gastroenterology,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)
出处
《医学综述》
2020年第16期3275-3281,3286,共8页
Medical Recapitulate
关键词
消化道良性狭窄
药物治疗
内镜下球囊扩张术
预防措施
Gastrointestinal benign stenosis
Drug treatment
Endoscopic balloon dilatation
Preventive measure
