摘要
目的:探讨二氧化碳(CO2)点阵激光及窄谱中波紫外线(NB-UVB)联合卤米松治疗白癜风的疗效及安全性。方法:抽取2019年4月至2020年2月河津市人民医院收治的稳定期白癜风患者49例。根据患者意愿将其分为治疗组(27例)与对照组(22例),治疗组给予CO2点阵激光、NB-UVB光疗联合卤米松治疗,对照组给予NB-UVB光疗联合卤米松治疗。比较两组患者临床疗效、色素积分、皮损面积、不良反应。结果:治疗组总有效率为96.30%(26/27),高于对照组的72.73%(16/22),χ2=5.499,P=0.019。治疗后,两组患者色素积分增加、皮损面积减小,且治疗组色素积分高于对照组、皮损面积低于对照组(P<0.05)。治疗组不良反应比率为7.41%(2/27),对照组良反应比率为22.73%(5/22),两组比较差异未见统计学意义(χ2=2.119,P=0.145)。结论:CO2点阵激光与NB-UVB光疗、卤米松联合治疗白癜风可促进皮损、色素恢复,且具有一定安全性。
Objective To investigate the efficacy and safety of CO2 fractional laser and narrowband ultraviolet B(UVB)combined with halometasone in the treatment of vitiligo.Methods A total of 49 patients with vitiligo in Hejin People’s Hospital from April 2019 to February 2020 were enrolled,and were divided into two groups according to patients’wiliness.Treatment group(27 cases)received CO2 fractional laser,narrowband UVB combined with Halometasone,while control group(22 cases)received UVB combined with Halometasone.Then the clinical efficacy,pigment score,skin injury area and adverse reactions were compared between the two groups.Results The total effective rate of the treatment group was 96.30%(26/27),which was higher than 72.73%(16/22)of the control group,χ2=5.499,P=0.019.The pigment score increased,and skin injury area was decreased,and treatment group had higher pigment score and smaller skin injury area than those of control group(P<0.05),the rate of adverse reactions in the treatment group was 7.41%(2/27),which in the control group was 22.73%(5/22),there was no statistical difference between the two groups(χ2=2.119,P=0.145).Conclusions Application of CO2 fractional laser,narrowband UVB combined with Halometasone can safely promote the recovery of patients with vitiligo.
作者
康娟
郝树媛
台永红
崔婷婷
陈小敏
Kang Juan;Hao Shuyuan;Tai Yonghong;Cui Tingting;Chen Xiaomin(Department of Dermatology,Hejin People’s Hospital,Hejin 043300,China;Department of Dermatology,Shanxi Provincial People’s Hospital,Taiyuan 030000,China)
出处
《中国实用医刊》
2020年第12期51-54,共4页
Chinese Journal of Practical Medicine
