摘要
目的应用超声射频信号血管内中膜分析(QIMT)技术和血管硬度定量分析(QAS)技术检测糖尿病患者颈动脉血管结构及弹性功能,探讨体质量指数(BMI)与其颈动脉血管损害的相关性。方法前瞻性选取我院糖尿病患者和性别、体质量与之相匹配的健康志愿者各90例(糖尿病组和对照组),根据体质量指数(BMI)将两组分别分成3个亚组即正常体质量亚组、超重亚组及肥胖亚组,每个亚组各30例。采用QIMT、QAS技术测量各组颈动脉内-中膜厚度(IMT)、颈动脉僵硬度指数(β)、脉搏波传播速度(PWV)及顺应性系数(CC),比较各组上述参数差异,并将颈动脉弹性参数与糖尿病史及BMI进行相关性分析。结果与对照组比较,糖尿病组颈动脉IMT、PWV及β值均明显增高,CC明显降低,差异均有统计学意义(均P<0.05)。随着BMI的增加,糖尿病组和对照组IMT、PWV、β均逐渐增高,CC逐渐下降(均P<0.05)。多变量分析显示,糖尿病史和BMI均与IMT和PWV独立相关(均P<0.05);与糖尿病史危险因素比较,BMI的增加对IMT和PWV的影响更大(标准化β=0.643、0.534,均P<0.001)。结论糖尿病和BMI均能独立引起糖尿病患者颈动脉血管结构和弹性功能损害,且BMI的增加较糖尿病对颈动脉血管结构及弹性功能的损害作用更大。
ObjectiveTo detect the vascular structure and elastic function of carotid artery in patients with diabetes by quality intima-media thickness(QIMT) and quality arterial stiffness(QAS) techniques,and to explore the correlation between body mass index(BMI)and carotid artery vascular damage.Methods A total of 90 diabetic patients and 90 healthy volunteers matched by gender and BMI were prospectively enrolled in this study(diabetes group and control group).The two groups were divided into 3 subgroups according to the BMI including normal body mass subgroup,overweight subgroup and obesity subgroup,with 30 cases in each subgroup.QIMT and QAS techniques were used to measure the intima-media thickness(IMT),stiffness index(β),pulse wave velocity(PWV)and compliance coefficient(CC)of common carotid artery in all subjects.The differences of the above parameters between groups were compared,and the correlation between carotid artery elasticity parameters and diabetes and BMI were analyzed.Results The values of carotid IMT,PWV and β in diabetes group were significantly higher than those in control group,while CC was lower than that in control group(all P<0.05).Also,IMT,PWV and β in diabetes group and control group increased with the increase of BMI,while CC decreased gradually(all P<0.05).Multivariate linear regression analysis showed that both diabetes and BMI were independently correlated with IMT and PWV(all P<0.05).Compared with the risk factors of diabetes,the increase of BMI had more influence on IMT and PWV(standardizedβ=0.643,0.534,both P<0.001).ConclusionBMI and diabetes cause the damage of carotid artery structure and elastic function independently,and the damage effect of increasing BMI on the structure and elastic function of carotid artery is more serious.
作者
苏瑾
罗秀霞
戈全荣
李萍
朱永胜
SU Jin;LUO Xiuxia;GE Quanrong;LI Ping;ZHU Yongsheng(Department of Ultrasonic Medicine,Shenzhen Hospital of Southern Medical University,Shenzhen 518100,China)
出处
《临床超声医学杂志》
CSCD
2020年第8期571-574,共4页
Journal of Clinical Ultrasound in Medicine
