摘要
口腔鳞状细胞癌(OSCC)具有高发病率、高病死率及不良预后等特点。具核梭杆菌(Fn)作为牙周病的主要致病菌之一,近年来已被流行病学证实与OSCC有一定的关系,且基础研究显示,Fn可能通过调节宿主基因,引起细胞因子和受体的改变,从而下调免疫细胞等的功能,影响OSCC的发生、发展。该文现对Fn与OSCC的关系作一综述。
Oral squamous cell carcinoma(OSCC)is associated with significant morbidity,mortality and poor prognosis.Fusobacterium nucleatum(Fn)as one of the predominant pathogens of periodontal diseases has been confirmed related to the OSCC by the epidemiology,and basic research has revealed that Fn may affected the incidence and development of OSCC by regulating the hosts′genes,altering the cytokins and receptors,thus reducing the immune reaction.This article reviews the relationship between Fn and OSCC.
作者
程兰欣(综述)
朱卓立(审校)
CHENG Lanxin;ZHU Zhuoli(State Key Laboratory of Oral Diseases/National Clinical Research Center for Oral Diseases/Department of Equipment,West China Hospital of Stomatology Sichuan University,Chengdu,Sichuan 610041,China)
出处
《重庆医学》
CAS
2020年第16期2767-2770,2774,共5页
Chongqing medicine
基金
大学生创新创业项目(C2019106414)。
关键词
口腔肿瘤
肿瘤
鳞状细胞
具核梭杆菌
分子机制
综述
mouth neoplasms
neoplasms
squamous cell
fusobacterium nucleatum
molecular mechanism
review
