摘要
目的探讨解郁汤联合电针百会、四神聪对脑梗死后抑郁焦虑患者的临床疗效及对神经功能的影响。方法将2016年4月—2018年3月医院收治的86例脑梗死后抑郁焦虑患者,随机分两组,为对照组和治疗组,各43例,对照组采用氟西汀胶囊(20 mg/次,1次/d)治疗,观察组采用解郁汤联合电针百会、四神聪治疗,持续治疗8周。比较两组患者的临床疗效,治疗前、治疗4周、治疗8周时记录汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)、24项汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)、神经功能缺损程度(National Institute of Health stroke scale,NIHSS)评分和5-羟色胺(5-hydroxytryptamine,5-HT)、去甲肾上腺素(Norepinephrine,NE)。结果对照组有效率81.40%(35/43)低于观察组95.35%(41/43),差异具有统计学意义(P<0.05)。与治疗前比,两组患者治疗4周、治疗8周时HAMA评分、HAMD评分及NIHSS评分降低;与对照组比,观察组患者治疗4周、治疗8周时HAMA评分、HAMD评分及NIHSS评分较低,差异具有统计学意义(P<0.05)。与治疗前比,两组患者治疗4周、治疗8周时血清5-HT和NE含量升高;与对照组比,观察组患者治疗4周、治疗8周时血清5-HT和NE含量较高,差异具有统计学意义(P<0.05)。对照组不良率18.60%(8/43)与观察组20.93%(9/43)比较,差异无统计学意义(P>0.05)。结论解郁汤联合电针百会、四神聪对脑梗死后抑郁焦虑患者的临床疗效确切,可改善焦虑、抑郁及神经缺损表现,提高血5-HT和NE水平,安全性高,是一种安全有效的治疗方案。
Objective To explore the clinical effect of Jieyu Decoction combined with electro-acupuncture at Baihui(DU20)and Sishencong(EX-HN1)on depression and anxiety after cerebral infarction and its influence on neurological function.Methods Eighty-six patients with depression and anxiety after cerebral infarction in our hospital from April 2016 to March 2018 were randomly divided intocontrol group and treatment group,43 cases in each group.The control group received fluoxetine capsule(20 mg/time,once a day).The observation group received Jieyu Decoction combined with electro-acupuncture at Baihui(DU20)and Sishencong(EX-HN1)for 8 weeks.The clinical efficacy was compared between the two groups.Hamilton Anxiety Scale(HAMA),24 Hamilton Depression Scale(HAMD),National Institute of Health Stroke Scale(NIHSS),5-hydroxytryptamine(5-HT),norepinephrine(Nor)and Epnephrine(NE)were recorded before treatment,4 and 8 weeks after treatment.Results The effective rate of the control group 81.40%(35/43)was lower than that of the observation group 95.35%(41/43)(P<0.05).Compared with those before treatment,the HAMA score,HAMD score and NIHSS score of the two groups were lower at 4 and 8 weeks of treatment.Compared with those of the control group,the HAMA score,HAMD score and NIHSS score of the observation group were lower at 4 weeks and 8 weeks of treatment(P<0.05).Compared with those before treatment,the serum levels of 5-HT and NE in the two groups increased after 4 and 8 weeks of treatment,while the serum levels of 5-HT and NE in the observation group were higher after 4 and 8 weeks of treatment than those in the control group(P<0.05).The adverse rate of the control group was 18.60%(8/43)and that of the observation group was 20.93%(9/43),and there was no significant difference between the two groups(P>0.05).Conclusion Jieyu Decoction combined with electro-acupuncture at Baihui(DU20)and Sishencong(EX-HN1)has a definite clinical effect on depression and anxiety after cerebral infarction.It can improve the manifestations of anxiety,depressi
作者
王能
林晓伟
张晓丽
冯琦钒
张光彩
赵瑾
WANG Neng;LIN Xiaowei;ZHANG Xiaoli;FENG Qivanadium;ZHANG Guangcai;ZHAO Jin(Hainan Provincial Hospital of Traditional Chinese Medicine,Haikou 570203,Hainan,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第7期40-43,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家重点基础研究发展计划(2014CB744604)。
关键词
解郁汤
电针百会、四神聪
脑梗死后抑郁焦虑
5-HT
NE
Jieyu Decoction
electro-acupuncture at Baihui(DU20)and Sishencong(EX-HN1)
depression and anxiety after cerebral infarction
5-HT
NE
