摘要
介孔二氧化硅纳米颗粒(mesoporous silica nanoparticles,MSNs)在进行药载系统的构建当中,不论是在靶向准确性,还是在控释性和缓释性等方面都表现出了独一无二的优越性。目前,关于该材料的体内毒性机制仍不十分清楚。笔者从体外实验和体内实验两个方面综述了MSNs的毒性效应。体外实验表明,MSNs可引起细胞氧化应激、细胞凋亡、细胞自噬、影响细胞周期;而体内试验表明,MSNs可引起心、肺、肾、脾等器官组织的毒性损伤。这为进一步进行MSNs的毒理学评价和安全使用提供参考依据,并展望了MSNs的未来研究方向。
Mesoporous silica nanoparticles(MSNs)have shown unique advantages in targeting accuracy,controlled-release and slow-release in the construction of drug loading system.At present,the mechanism of toxicity of MSNs in vivo is still not clear.The toxicity of MSNs in vitro and in vivo was introduced in the review.The in vitro experiments have shown that MSNs can cause oxidative stress,cell apoptosis,autophagy and cell cycle change,while in vivo experiments have shown that MSNs can cause toxic damage to organs such as heart,lung,kidney and spleen.This paper provided reference for further toxicological evaluation and safe use of MSNs,and predicted the future research direction of MSNs.
作者
钟健
孙晨瑞
朱佳瑞
梁明达
张金波
ZHONG Jian;SUN Chen-rui;ZHU Jia-rui;LIANG Ming-da;ZHANG Jin-bo(Clinical Class 7 of Basic Medical College in 2017,Jiamusi University,Heilongjiang 154007,China;不详)
出处
《环境与健康杂志》
CAS
北大核心
2019年第12期1111-1115,共5页
Journal of Environment and Health
基金
黑龙江省卫生计生委立项科研课题(2014-265)
2018年黑龙江省大学生创新训练计划(201810222068)。
关键词
MSNs
功能化
细胞毒性
体内毒性
Mesoporous silica nanoparticles(MSNs)
Functionalization
Cytotoxicity
Toxicity in vivo
