摘要
目的观察自拟消风汤配合针灸治疗急性痛风性关节炎的疗效。方法随机将方便选取2016年12月—2018年12月该院收治的70例患者分成两组,观察组35例给予自拟消风汤配合针灸治疗,对照组给予秋水仙碱治疗。治疗3周后,比较两组患者临床疗效及,并观察关节肿胀、疼痛、压痛评分及炎性相关因子白细胞介素-1β(IL-1β)、血清环氧合酶-2(COX-2)、肿瘤坏死因子(TNF-α)情况,评价两组不良反应情况。结果观察组总有效率为94.29%,显著高于对照组的77.14%,差异有统计学意义(χ^2=4.200,P=0.040);治疗后观察组关节肿胀、疼痛、压痛评分分别为(0.39±0.09)分、(0.45±0.11)分、(0.48±013)分,显著低于对照组的(0.96±0.21)分、(1.50±0.31)分、(1.15±0.56)分(t=14.760、18.885、6.895,P=0.000、0.000、0.000),且两组治疗后各项评分均较治疗前降低,差异有统计学意义(P<0.05);治疗后观察组IL-1β、COX-2、TNF-α分别为(20.09±11.65)、(10.34±3.12)、(21.45±6.31)pg/mL,低于对照组的(27.12±12.12)、(15.31±6.41)、(31.11±6.98)pg/mL,差异有统计学意义(t=2.474、4.124、6.074,P=0.016、0.000、0.000);观察组不良反应率8.57%,显著低于对照组的28.57%,差异有统计学意义(χ^2=4.629,P=0.031)。结论自拟消风汤配合针灸治疗急性痛风性关节炎通过多靶点及多环节阻断或减轻关节炎症反应,起到抑制急性痛风的病情发展,缓解临床症状,安全可靠,操作简单。
Objective To observe the effect of self-made Xiaofeng Decoction combined with acupuncture on acute gouty arthritis.Methods A total of 70 patients admitted to the hospital from December 2016 to December 2018 were convenient selection randomly divided into two groups.Observation group 35 cases were given self-made Xiaofeng Decoction combined with acupuncture treatment,and control group was given colchicine treatment.After 3 weeks of treatment,the clinical efficacy and the results of joint swelling,pain,tenderness and inflammation-related factors interleukin-1β(IL-1β)and serum cyclooxygenase-2(COX-2),tumor necrosis factor(TNF-α)situation were compared between the two groups,to evaluate the adverse reactions in the two groups.Results The total effective rate of the observation group was 94.29%,significantly higher than that of the control group of 77.14%,the difference was statistically significant(χ^2=4.200,P=0.040);after treatment,the joint swelling,pain,and tenderness scores of the observation group were(0.39±0.09)points,(0.45±0.11)points,(0.48±013)points,significantly lower than the control group(0.96±0.21)points,(1.50±0.31)points,(1.15±0.56)points(t=14.760,18.885,6.895,P=0.000),and the scores of the two groups after treatment are lower than before treatment,the difference was statistically significant(P<0.05);after treatment,the observation group IL-1β,COX-2,TNF-αwere respectively(20.09±11.65)pg/mL,(10.34±3.12)pg/mL,(21.45±6.31)pg/mL,lower than the control group(27.12±12.12)pg/mL,(15.31±6.41)pg/mL,(31.11±6.98)pg/mL,the difference was statistically significant(t=2.474,4.124,6.074,P=0.016,0.000,0.000);the adverse reaction rate of the observation group was 8.57%,significantly lower than the control group 28.57%,the difference was statistically significant(χ^2=4.629,P=0.031).Conclusion Self-made Xiaofeng Decoction combined with acupuncture and moxibustion for the treatment of acute gouty arthritis through multi-targets and multiple links to block or reduce joint inflammation,play a role in inhibit
作者
钟亮玉
ZHONG Liang-yu(Department of Endocrinology,Yunyang District Traditional Chinese Medicine Hospital,Shiyan,Hubei Province,442500 China)
出处
《中外医疗》
2020年第17期183-185,共3页
China & Foreign Medical Treatment
关键词
急性痛风性关节炎
自拟消风汤
针灸
炎性因子
Acute gouty arthritis
Self-made Xiaofeng Decoction
Acupuncture
Inflammatory factors
