摘要
目的比较不同剂量丙种球蛋白治疗川崎病的临床疗效,探讨丙种球蛋白治疗川崎病的最优方案。方法将纳入标准的川崎病患儿随机分为3组,观察对比3组患儿临床结局、症状消退时间、实验室指标恢复情况及相关并发症的发生情况。结果①B组(每日1g/kg组)及C组(每日2g/kg组)治愈率均高于A组(每日400mg/kg组)。②B组及C组症状消退时间均短于A组。③C组患儿实验室指标治疗后均低于治疗前。④B组及C组患儿治疗期间心血管并发症低于A组。结论静脉滴注丙种球蛋白每日2g/kg治疗1d与每日1g/kg连用2d两种方案治疗川崎病能更快速控制各临床症状、改善各项指标,有助于恢复,且治愈率高。
Objective To compare the clinical effect of different dose of Gammaglobulin in the treatment of Kawasaki Disease(KD),and explore the best scheme of treatment of KD with Gammaglobulin.Methods Children with Kawasaki Disease were randomly divided into 3 groups to observe and compare the clinical outcome symptom disappearance time,the recovery of laboratory indexes and the occurrence of related complications.Results ①The cure rate of B groups(1 g/kg daily) and C groups(2 g/kg daily) was higher than that of A Group(400 mg/kg daily).②The time of symptom subsiding in group B and C was shorter than that in Group A.③The laboratory indexes of C groups were lower after treatment than before treatment.④The cardiovascular complications in Group B and C were lower than that in Group A.Conclusion The two regimens of intravenous Immunoglobulin(Ivig) 2 g/kg per day for 1 day and 1 g/kg per day for 2 days can both control the clinical symptoms and improve the indexes of Kawasaki Disease more quickly,which remarkely shorten the recovery time and have a high cure rate.
作者
胡家华
张永峰
HU Jialiua;ZHANG Yongfeng(Department of Pediatrics,the Affiliated Hospital of Weifang Medical University,Weifang 261031,China)
出处
《潍坊医学院学报》
2020年第3期164-166,共3页
Acta Academiae Medicinae Weifang
关键词
川崎病
丙种球蛋白
不同剂量
临床疗效
Kawasaki disease
Gamma globulin
Different dosage
Clinical effect
