摘要
目的:评价氟比洛芬酯联合舒芬太尼超前镇痛对口腔癌手术患者疼痛的疗效及安全性。方法:选择2017年7月到2019年7月行口腔癌手术治疗的156例患者作为研究对象,应用随机数字表法分为对照A组、对照B组和联合组,各52例。其中对照A组患者行口腔癌手术后给予舒芬太尼镇痛,对照B组患者行口腔癌手术后给予氟比洛芬酯联合舒芬太尼镇痛,联合组患者术前给予氟比洛芬酯联合舒芬太尼超前镇痛。比较分析三组患者围手术期各时间点的疼痛程度、镇静程度,术后慢性疼痛发生率,不良反应发生率。结果:联合组患者术后0、1、3、5、12、24 h的疼痛评分显著低于对照A组和对照B组,差异均有统计学意义(P<0.05)。联合组患者术后0、1、3、5、12、24 h的Ramsay镇静评分显著优于对照A组和对照B组,差异均有统计学意义(P<0.05)。联合组患者术后1、2、3个月的慢性疼痛发生率分别为1.92%、0和0,显著低于对照A组和对照B组,差异有统计学意义(P<0.05)。联合组患者围手术期不良反应发生率为1.92%,显著低于对照A组的34.62%和对照B组的15.38%,差异有统计学意义(P<0.05)。结论:应用氟比洛芬酯联合舒芬太尼超前镇痛对口腔癌手术患者进行干预,显著降低围手术期疼痛程度,优化镇静效果,降低术后慢性疼痛发生率和不良反应发生率,值得广泛推广。
Objective:To evaluate the efficacy and safety of flurbiprofen axetil combined with sufentanil for preemptive analgesia in patients undergoing oral cancer surgery.Methods:156 patients who were operated on for oral cancer from July 2017 to July 2019 were selected as the study objects.The patients were divided into control group A,control group B and combination group with 52 cases in each group.The patients in the control group A received sufentanil analgesia after the operation of oral cancer.The patients in the control group B received flurbiprofen axetil combined with sufentanil analgesia after the operation of oral cancer,and the patients in the combined group received flurbiprofen axetil combined with sufentanil preemptive analgesia before the operation.The degree of pain and sedation,the incidence of chronic pain and adverse reactions were compared among the three groups.Results:In the combined group,the pain scores at 0,1,3,5,12 and 24 hours were significantly lower than those in the control group A and B(P<0.05).The Ramsay sedation score of the combined group was significantly better than that of the control group A and the control group B(P<0.05).The incidence of chronic pain in the combined group was 1.92%,0 and 0 at 1,2 and 3 months after operation,which was significantly lower than that in the control group A and B(P<0.05).The incidence of adverse reactions in the combined group was 1.92%,which was significantly lower than 34.62%in the control group A and 15.38%in the control group B(P<0.05).Conclusion:The application of flurbiprofen axetil combined with sufentanil for preemptive analgesia in maxillofacial surgery patients can significantlyreduce perioperative pain,optimize sedation effect,reduce the incidence of postoperative chronic pain and adverse reactions,which is worth popularizing.
作者
张春谊
廖习坪
周宁
焦烨子
张倩
闫英英
刘伟
王楠
刘蕊
Zhang Chunyi;Liao Xiping;Zhou Ning;Jiao Yezi;Zhang Qian;Yan Yingying;Liu Wei;Wang Nan;Liu Rui(State Key Laboratory of Military Stomatology&National Clinical Research Center of Oral Diseases&Shaanxi Clinical Research Center of Oral Diseases,the Third Affiliated Hospital of Air Force Medical University,Shaanxi Xi'an 710032,China)
出处
《现代肿瘤医学》
CAS
2020年第18期3150-3154,共5页
Journal of Modern Oncology
基金
陕西省社会发展科技攻关项目(编号:2015SF216)。
关键词
氟比洛芬酯
舒芬太尼
口腔癌
手术
安全性
flurbiprofen axetil
sufentanil
oral cancer
operation
safety
