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子宫浆液性癌的起源及临床研究进展

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摘要 子宫浆液性癌(uterine serous carcinoma,USC)是子宫内膜癌的少见类型,发病率占子宫内膜癌的3%~10%[1],为非激素依赖的特殊组织类型,即雌孕激素受体(ER/PR)多为阴性,肿瘤的发生生长与雌激素刺激无关。临床表现不常伴有肥胖、高血压、糖尿病等,称为Ⅱ型子宫内膜癌[2]。USC临床虽少见,但其恶性程度高,USC的5年总生存率(OS)为18%~27%[3],病死率占子宫内膜癌的39%[3]。研究显示,早期[国际妇产科联盟(FIGO)Ⅰ~Ⅱ期]子宫内膜癌病例中Ⅰ型子宫内膜癌的5年生存率为80%~90%,而USC仅为50%~72%[4]。
作者 韩瑛 刘崇东
出处 《中国实用妇科与产科杂志》 CAS CSCD 北大核心 2020年第8期779-781,共3页 Chinese Journal of Practical Gynecology and Obstetrics
基金 国家高技术研究发展计划(2014AA020606)。
关键词 子宫内膜恶性肿瘤 手术 联合放化疗 分子靶向治疗 endometrial malignancy surgery combined chemotherapy and radiotherapy molecular targeting treatment
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