摘要
目的:研究中药辅助腰椎间盘突出患者行微创椎间孔镜技术(PTED)治疗的临床疗效及血浆超敏C-反应蛋白(hs-CRP)、肌酸磷酸激酶(CPK)、白细胞介素-6(IL-6)水平的变化。方法:选取我院2014年2月—2017年6月收治的腰椎间盘突出患者72例,分为两组,常规组36例行椎板开窗手术治疗,研究组36例行微创椎间孔镜手术治疗,为两组患者在术后3天开始服用独活寄生汤,分别于术前、术后3、6、12、24及48 h检测血浆hs-CRP、CPK、IL-6水平情况,并比较两组患者术中出血量、住院时间及伤口大小等情况。结果:研究组术中出血量(6.7±3.4)m L显著低于常规组(82.6±16.5)mL,差异有统计学意义(t=28.136,P<0.05);研究组住院时间(2.4±0.6)d显著短于常规组(5.7±1.4)d;差异有统计学意义(P<0.05);研究组伤口大小(0.5±0.1)cm显著小于常规组(5.0±1.3)cm,差异有统计学意义(P<0.05);常规组血清IL-6与CPK均在术后3 h出现明显升高,而研究组均在术后6 h升高,但研究组血清IL-6与CPK水平均显著低于常规组,差异均有统计学意义(P均<0.05);常规组血清hs-CRP在术后6 h出现明显升高,而研究组在术后12 h出现明显升高,两组均在术后24 h达峰值,但研究组血清hs-CRP水平显著低于常规组,差异有统计学意义(P<0.05)。结论:中药独活寄生汤辅助PTED治疗腰椎间盘突出对患者身体损伤小,且能达到与椎板开窗手术治疗的相同疗效。
Objective To explore the clinical effect of Traditional Chinese medicine assisted minimally invasive percutaneous endoscopic technique(PTED)in the treatment of lum bar disc herniatien and the changes of high sensitivity C-reaction protein(hs-CRP),creatine phosphate kinase(CPK)and interleukin-6(IL-6)of plasma factor.Methods 72 cases of lum bar disc herniatienin in our hospital during February 2014 to June 2017 were randomly divided into 2 groups.36 cases of conventional group were received vertebral lamina fenestration surgery and 36 cases in the study group were received minimally invasive percutaneous endoscopic surgery.The patients in both groups began to take Duhuo Jisheng decoction 3 days after operation.The data of hs-CRP,CPK,IL-6 of two groups were recorded preoperative and postoperative 3,6,12,24 and 48 h respectively and they were compared with intraoperative blood loss,length of stay and wound size.Results The intraoperative blood loss(6.7±3.4)mL in the study group was significantly lower than that in the conventional group(82.6±16.5)mL,which the difference was statistically significant(t=28.136,P<0.05).The length of stay of the study group(2.4±0.6)d was significantly shorter than that of the conventional group(5.7±1.4)d,which the difference was statistically significant(P<0.05).The wound size(0.5±0.1)cm in the study group was significantly smaller than that of the conventional group(5±1.3)cm(P<0.05).3 hours after surgery,the serum level of IL-6 and CPK in the conventional group were significantly increased,while the study group were elevated after 6 hours(P<0.05).The level of serum hs-CRP in the conventional group was higher than that of the study group and it significantly increased 6 hours after surgery,while the study group increased after 12 hours,and both of them were peaked after 24 hours(P<0.05).Conclusion Traditional Chinese Medicine Duhuo Jisheng decoction which assisted PTED treatment can achieve the same effect as vertebral lamina fenestration surgery with low damages.
作者
于亚东
刘孟军
YU Ya-dong;LIU Meng-jun(Department of Spine and Trauma Orthopaedics,Yunyang County Peoples’Hospital,Chongqing(404500),China)
出处
《中国中西医结合外科杂志》
CAS
2020年第4期662-665,共4页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
腰椎间盘突出症
独活寄生汤
椎间孔镜技术
疗效
Lum bar disc herniatien
Duhuo Jisheng decoction
percutaneous transforaminal endo-scopic discectomy
effect
