摘要
细菌性脑膜炎(bacterial meningitis,BM)是儿童,尤其是36月龄以下婴幼儿最常见的颅脑急性感染性疾病。随着预防措施的普及、抗生素的革新,BM的发病率明显下降,但病死率与致残率仍居高不下,尤其在低收入的亚非拉国家有1/3~1/2的随访患儿留有永久性神经系统后遗症,极大降低了儿童生存质量,加重家庭及社会负担。对于导致BM预后不良相关危险因素的研究较多,目前较为认可的危险因素包括病原菌、年龄小(1岁以内)、临床表现重(惊厥、意识障碍等)及炎症指标高,现介绍影响BM预后的危险因素的最新研究进展。
Bacterial meningitis(BM)is the most commonly acute infectious disease of children,especially for infants under 36 months of age.With the popularization of preventive measures and the innovation of antibiotics,the incidence rate has dropped,but the mortality rate and disability rate remain high.Especially in low-income Asian African countries,1/3-1/2 has a permanent neurological sequela,which greatly reduces the quality of life of children.Increase the family and social burden.There are numerous studies on the risk factors that lead to poor prognosis of BM.At present,the more recognized risk factors include pathogenic bacteria,younger age(less than 1 year old),severe clinical manifestations(convulsion,disturbance of consciousness,etc.)and high inflammation index.This paper briefly introduces the latest research progress on the risk factors that affect the prognosis of BM.
作者
李阳
图雅
王育民
LI Yang;TU Ya;WANG Yumin(Inner Mongolia Medical University Graduate School,Hohhot 010020,China;Inner Mongolia Maternal and Child Health Hospital,Hohhot 010010,China)
出处
《中国实用神经疾病杂志》
2020年第15期1374-1380,共7页
Chinese Journal of Practical Nervous Diseases
基金
内蒙古自治区自然基金(编号:2017MS0819)。
关键词
儿童
细菌性脑膜炎
病原菌
惊厥
意识障碍
Children
Bacterial meningitis
Pathogenic bacteria
Convulsions
Disturbance of consciousness
