摘要
The target compounds 3(C14H15NO4)and 4(C20H17NO8)were synthesized and structurally determined by single-crystal X-ray diffraction.The crystal of 3 is in the monoclinic system,space group P21/c with a=7.3017(3),b=7.8737(5),c=22.4227(11)?,β=94.837(5)°,C14H15NO4,Mr=261.27,Dc=1.351 g/cm3,V=1284.51(11)?3,Z=4,F(000)=552,μ(MoKa)=0.828 mm–1,T=289.12(10)K,2236 independent reflections with 1827 observed ones(I>2σ(I)),R=0.0515 and w R=0.1394 with GOF=1.044(R=0.0605 and w R=0.1548 for all data).The crystal of compound 4 is in the monoclinic system,space group P21/c with a=7.1269(3),b=12.6518(6),c=20.7540(8)?,β=96.941(4)°,C20H17NO8,Mr=399.35,Dc=1.428 g/cm3,V=1857.61(14)?3,Z=4,F(000)=832.0,μ(MoKa)=0.950 mm–1,T=288.81(10)K,3216 independent reflections with 2253 observed ones(I>2σ(I)),R=0.0612 and wR=0.1548 with GOF=1.055(R=0.0824 and w R=0.1790 for all data).The skeleton of 1,4-dihydroquinoline 3 is noncoplanar,while pyrrolo[1,2-a]-quinoline 4 owns a coplanar frame structure.One-dimensional interaction model of compound 4 was formed by the one kind ofπ-πinteraction between the two adjacent molecules at upper and lower levels.And the inhibition to the strand transfer process of HIV-1 integrase of the title compounds was also evaluated.
基金
supported by the Natural Science Research Projects in Colleges and Universities of Anhui Province(No.KJ2019A0116)
Natural Science Foundation of Anhui Province(No.1608085MB38)。
