摘要
目的探究暴露于室外空气污染中PM 2.5对肺癌发病风险的关联性。方法以“颗粒物”、“细颗粒物”、“肺癌”、“particulate matter”、“PM 2.5”、“lung cancer”、“lung carcinoma”、“incidence”、“morbidity”等为检索词,检索数据库PubMed、Embase、Web of Science、中国知网数据库(CNKI)、万方数据库自建库至2020年4月有关于PM 2.5与肺癌发病率相关的队列研究,对纳入研究采用NOS量表进行质量评价并使用Stata 15.1软件进行Meta分析。结果共纳入6篇队列研究,经异质性检验后选择固定效应模型(P>0.1,I 2<50%)。Meta分析合并效应量RR值为1.07(95%CI:1.06~1.09),提示暴露于空气污染中的PM 2.5每上升10μg/m 3可能会增加肺癌的发生风险。进行敏感性分析后结果显示剔除任一研究合并效应量均未发生明显改变,提示此次Meta分析的结果较为稳健。结论随着暴露于空气污染中的PM 2.5的上升肺癌发生风险可能会增加。
Objective To evaluate relationship between PM 2.5 exposure and the risk of lung cancer.Methods Searched Chinese literatures with cohort studies from CNKI and Wanfang databases and English literatures with cohort studies from Pubmed,Embase,and Web of Science(from inception to April 2020),and the key words were"particulate matter"、"particle"、"PM 2.5"、"lung cancer"、"lung carcinoma"、"lung tumor"、"lung tumour"、"lung neoplasm"、"lung adenocarcinoma"、"incidence"、"morbidity".Used NOS to assess the quality of these studies,and used Stata 15.1 software to perform meta-analysis.Results A total of 6 articles were included.The fixed effect model was selected after heterogeneity test.(P>0.1,I 2<50%)The Meta-analysis showed that the risk of lung cancer may increase for per 10μg/m 3 of PM 2.5 exposure(pooled RR=1.07,95%CI:1.06-1.09).The results of sensitivity analysis showed that no significant changes in the combined effect were observed after excluding any study,indicating that the results of this meta-analysis were relatively stable.Conclusion The risk of lung cancer may increase with increased exposure to PM 2.5 in air pollution.
作者
白羽
倪洋
曾强
BAI Yu;NI Yang;ZENG Qiang(School of Public Health,Tianjin Medical University,Tianjin 300070,China;Tianjin Center for Disease Control and Prevention,Tianjin 300011,China)
出处
《公共卫生与预防医学》
2020年第4期5-8,共4页
Journal of Public Health and Preventive Medicine
基金
国家自然科学基金面上项目(81872590)。
