摘要
目的比较不同程度T2DM合并DR患者血清25羟维生素D[25(OH)D]、鸢尾素(Irisin)水平差异,探讨其在DR发生发展中的意义。方法选取2018年5月至2019年3月于遵义医科大学附属医院内分泌科门诊及住院治疗的T2DM患者240例,分为单纯T2DM患者(T2DM组)、合并非增殖型DR(NPDR)组及增殖型DR(PDR)组,每组各80例。另选取同期我院体检中心年龄相匹配的健康人群88名为正常对照(NC)组。ELISA法检测Irisin水平,电化学发光法检测25(OH)D水平。结果NC组25(OH)D、Irisin水平高于T2DM、NPDR及PDR组[(35.67±5.06)vs(20.11±4.40)vs(13.60±5.37)vs(4.71±1.83)ng/ml,(278.48±11.15)vs(202.55±9.27)vs(154.25±9.25)vs(104.58±8.88)ng/ml,P<0.05];Logistic回归分析显示,TG、HbAlc、25(OH)D、Irisin是DR的影响因素。结论血清25(OH)D、Irisin水平降低可能引起糖脂代谢紊乱,导致不同程度DR。
Objective To explore the potential roles of serum 25 hydroxyvitamin D[25(OH)D] and irisin in the process of diabetic retinopathy.(DR)Methods type 2 diabetes mellitus(T2DM)patients were enrolled in First Affiliated Hospital of Zunyi Medical College.The patients were divided into simple T2DM patients(T2DM group),non proliferative diabetic retinopathy(NPDR)group and proliferative diabetic retinopathy(PDR)group,with 80 cases in each group.88 age-matched healthy people from the physical examination center in the same period were selected as the normal control(NC)group.Irisin was detected by ELISA and 25(OH)D was detected by electrochemilumiThe serum levels of 25(OH)D and irisin in NC group were significantly higher than those in T2DM,NPDR and PDR group[(35.67±5.06)vs(20.11±4.40)vs(13.60±5.37)vs(4.71±1.83)ng/ml,(278.48±11.15)vs(202.55±9.27)vs(154.25±9.25)vs(104.58±8.88)ng/ml,P<0.05].Logistic regression analysis showed that the levels of TG,HbAlc,25(OH)D and irisin were ConclusionThe lower levels of 25(OH)D and irisin may be related to DR by affecting glucose metabolism and lipid metabolism.
作者
姚杨
胡皓铭
张子扬
阳琰
王哲
罗丽娅
樊思桐
YAO Yang;HU Haoming;ZHANG Ziyang(Department of Endocrinology,First Affiliated Hospital of Zunyi Medical College,Zunyi 563000,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2020年第7期521-524,共4页
Chinese Journal of Diabetes
基金
国家自然科学基金(81460168)
贵州省科技厅自然科学基金资助项目(黔科合基础[2020]1Y314)
贵州省科学技术基金(黔科合J字LKZ[2013]19号)
遵义市联合基金(遵市科合社字[2018]63)
遵义医科大学新苗培养及创新探索专项后补助课题(黔科合平台人才[2017]5733-043)。
