摘要
目的探讨帕利哌酮与奥氮平治疗精神分裂症的效果。方法选取南京医科大学无锡精神卫生中心2018年1月至2019年6月收治的精神分裂症患者100例为研究对象,根据治疗方法分成帕利哌酮组和奥氮平组,每组50例。对比两组的治疗效果。结果治疗6周后,两组的治疗有效率比较差异未见统计学意义(P>0.05),且不良反应发生率比较,差异未见统计学意义(P>0.05)。治疗2周、4周后帕利哌酮组的阳性与阴性症状量表(PANSS)、阳性症状评分、阴性症状评分和一般病理评分均低于奥氮平组,差异有统计学意义(P<0.05)。治疗6周后的PANSS评分比较,组间差异未见统计学意义(P>0.05)。治疗6周后帕利哌酮组的社会功能量表(PSP)评分[(71.7±3.8)分]高于奥氮平组[(62.1±3.5)分],差异有统计学意义(P<0.05)。结论帕利哌酮和奥氮平治疗精神分裂症的疗效相当,不良反应发生率无差异,但帕利哌酮的见效快,且利于患者社会功能改善,值得推广。
Objective To investigate the effects of paliperidone and olanzapine on schizophrenia.Methods One hundred patients with schizophrenia admitted to Wuxi Mental Health Center Affiliated to Nanjing Medical University from January 20 to June 2019 were enrolled.The patients were divided into the paliperidone group and the olanzapine group according to the treatment method,with 50 cases in each group.The therapeutic effects of the two groups were compared.Results After 6 weeks of treatment,there was no significant difference in the effective rate between the two groups,and there was no significant difference in the incidence of adverse reactions(P>0.05).The PANSS score,positive symptom score,negative symptom score and general pathological score after 2 weeks and 4 weeks of treatment were lower in paliperidone group than those in olanzapine group(P<0.05).The PANSS scores after 6 weeks of treatment were not significantly different between the groups(P>0.05).The PSP scores after 6 weeks of treatment were higher in the paliperidone group[(71.7±3.8)scores]than those in the olanzapine group[(62.1±3.5)scores],the difference was significant(P<0.05).Conclusions Palipe ridone and olanzapine have similar efficacy and few adverse reactions in the treatment of schizophrenia,but paliperidone has quick effect and is beneficial to the improvement of social function of patients,which is worthy of promotion.
作者
周勤
Zhou Qin(Department of Pharmacy,Wuxi Mental Health Center Affiliated to Nanjing Medical University,Wuxi 214151,China)
出处
《临床医学》
CAS
2020年第5期86-88,共3页
Clinical Medicine
