摘要
免疫逃逸作为肿瘤的特征之一,在肿瘤进展中发挥着重要作用。癌相关成纤维细胞(CAFs)是肿瘤微环境(TME)中最丰富、最关键的成分之一,通过重塑细胞外基质,促进肿瘤的发生、发展。CAFs是TME中免疫调节的主要参与者,通过多种机制使TME处于免疫抑制状态,促进肿瘤的免疫逃逸,包括多种细胞因子和趋化因子的分泌、介导先天和获得性免疫细胞的募集和功能分化以及对肿瘤细胞本身的免疫调控等。通过开发靶向CAFs的药物,可能中断成纤维细胞与肿瘤之间的相互作用,消除免疫抑制状态,从而抑制肿瘤的发生、发展。
Immune escape,as one of the characteristics of tumor,plays an important role in tumor progression.Cancer-associated fibroblasts(CAFs)are one of the most abundant and critical components in tumor microenvironment(TME),which can promote the occurrence and development of tumors by remodeling extracellular matrix.CAFs are the main participant in immune regulation of TME,which makes TME in an immunosuppressive state through a variety of mechanisms and promotes tumor immune escape,including secretion of various cytokines and chemokines,mediation of recruitment and functional differentiation of innate and acquired immune cells,and immune regulation of tumor cells themselves.The development of drugs targeting CAFs may interrupt the interaction between fibroblasts and tumors,eliminate immunosuppression,and thus inhibit the occurrence and development of tumors.
作者
袁海铭
何永文
YUAN Haiming;HE Yongwen(Department of Oral and Maxillofacial Surgery,Affilicated Stomatological Hospital of Kunming Medical University,Kunming 650106,China)
出处
《医学综述》
2020年第15期2957-2963,2969,共8页
Medical Recapitulate
基金
国家自然科学基金(81660448)
云南省科技计划项目(2017FE468(-006))。
关键词
癌相关成纤维细胞
肿瘤微环境
免疫抑制
靶向治疗
Cancer-associated fibroblasts
Tumor microenvironment
Immunosuppression
Targeted therapy
