摘要
目的:探讨脓毒症中医证型与血浆糖基化终末产物的可溶性受体(sRAGE)之间的关系。方法:93例脓毒症患者按照证型分为热毒内盛组30例、气虚热瘀组35例、阳气亏脱组28例,收集各组急性生理与慢性健康评分(APACHEⅡ),检测血乳酸(Lac)、sRAGE浓度。结果:阳气亏脱组患者脓毒症休克人数、血Lac浓度[(6.34±2.01)mmol/L VS(4.46±1.22)mmol/L、(5.12±1.58)mmol/L]及APACHEⅡ评分[(22.15±7.28)分VS(15.74±5.42)分VS(17.68±6.56)分]明显高于热毒内盛组与气虚热瘀组,差异有统计学意义(P<0.05)。血浆sRAGE浓度,阳气亏脱组(2253.6±237.1)pg/mL>热毒内盛组(1583.4±163.5)pg/m L>气虚热瘀组(1452.1±136.8)pg/mL,组间比较差异有统计学意义(P<0.05)。病死组血浆sRAGE浓度显著高于存活组[(2406.7±256.4)pg/mL VS(1310.3±159.4)pg/mL],差异有显著统计学意义(P<0.01)。结论:sRAGE是一项可反映脓毒症病情及预后的无创指标,还可作为反映机体正邪抗争强度的外在观察指标,值得进一步深入研究。
Objective:To explore the relationship between the TCM syndrome types of sepsis and the level of plasma sRAGE.Methods:93 patients with sepsis were divided into three groups according to the syndrome type:30 cases in the Redu Neisheng type(热毒内盛)group,35 cases in the Qixu Reyu type(气虚热瘀)group and 28 cases in the Yangqi Kuituo(阳气亏脱)group.APACHEⅡscores were collected,and the concentrations of Lac and sRAGE in blood were measured ingroups.Results:The number of septic shock patients,Lac concentration and APACHEⅡscore in the Yangqi Kuituo type group were significantly higher than the Redu Neisheng type group and the Qixu Reyu type(P<0.05).There were significant difference of sRAGE among groups(the Yangqi Kuituo type>the Redu Neisheng type>the Qixu Reyu type).The plasma sRAGE concentration in the death group was significantly higher than the survival group,P<0.01.Conclusion:sRAGE is a noninvasive index which can reflect the condition and prognosis of sepsis and the intensity of the struggle between Zheng(正)and Xie(邪).
出处
《中医临床研究》
2020年第19期8-10,共3页
Clinical Journal Of Chinese Medicine
基金
广州市中医药和中西医结合科技项目,编号:20182A011027。
