摘要
放射性皮肤损伤是头颈癌、鼻咽癌等患者放射治疗常见且较为严重的不良反应,不仅限制了肿瘤的放疗剂量,且严重影响患者的后续治疗及生活质量,成为提高肿瘤疗效的瓶颈。放射性皮肤损伤的发生是多种因素相互作用的复杂过程,与患者自身因素、放疗技术、放疗剂量分割方案、放化疗方案等密切相关。不同放化疗方案以及不同药物联合治疗对急性皮肤损伤的发生发展存在影响,且临床上尚缺乏对放射性皮肤损伤有效的防治办法。因此,探讨其发生机制及不同放化疗方案所致放射性皮肤损伤等具有重要意义。文章主要就同步放化疗、诱导和辅助化疗的联合应用加重放射性皮肤损伤及相关机制等方面进行综述。
Radiation skin injury is a common and severe adverse event of radiotherapy in patients with head and neck cancer or nasopharyngeal carcinoma,which not only limits the radiation dose of the tumor,but also seriously affects the follow-up treatment and quality of life of the patients.It has become a bottleneck to improve the curative effect of tumor.The occurrence of radiation skin injury is a complex process of the interaction of many factors,which is closely related to the patient's own factors,radiotherapy technology,radiotherapy dose segmentation scheme and the combined regimens of radiotherapy and chemotherapy.Different regimens of radiotherapy and chemotherapy with drugs have effects on the occurrence and development of acute skin injury.There is still a lack of effective prevention and treatment of radiation-induced skin injury.Therefore,it is of great significance to explore its mechanism and radiation skin damage caused by different radiotherapy and chemotherapy regimens.This paper mainly reviews the combined application of concurrent chemoradiotherapy,induction and adjuvant chemotherapy to aggravate skin injury and its related mechanisms.
作者
姚泽欣(综述)
程飚(审校)
YAO Ze-xin;CHENG Biao(School of Public Health,Guangdong Pharmaceutical University,Guangzhou 510310,Guangdong,China)
出处
《医学研究生学报》
CAS
北大核心
2020年第8期861-866,共6页
Journal of Medical Postgraduates
基金
国家自然科学基金(81671924)
国家重点研发计划(2017YFC1103301)。
关键词
放射性皮肤损伤
诱导化疗
同步放化疗
调强放疗
三维适形放疗
radiation-induced skin injury
induction chemotherapy
concurrent chemoradiotherapy
intensity modulated radiotherapy
three-dimensional conformal radiotherapy
