摘要
目的探讨丹参酮ⅡA对急性心梗大鼠再灌注损伤的保护作用。方法选取30只SD大鼠,建立血瘀模型,随机分为假手术组(Sham组)、AMI对照组(Control组)及丹参酮ⅡA干预组(TSN组)。Sham组只开胸穿线不结扎,Control组与TSN组建立心梗再灌注模型。造模前、再灌注4周后观察各组的超声心动图,再灌注4周后比较各组的血流动力学结果。结果超声心动图结果显示Control组的左室收缩末内径(LVIDs)和左室舒张末内径(LVIDd)较Sham组扩大(P<0.05),左室射血分数及左室短轴缩短率较假手术组降低(P<0.05);TSN组与Control组相比,LVIDs及LVIDd有改善(P<0.05),且LVEF%及FS%得到提高(P<0.05)。血流动力学结果显示,再灌注4周后,Control组与假手术组比较,可见HR加快、LVSP下降、LVEDP升高(P<0.05);与Control组比较,TSN组能升高LVSP,降低LVEDP,差异有统计学意义(P<0.05),但HR则无差异(P>0.05)。结论丹参酮ⅡA可改善血瘀型大鼠急性心梗后的心功能。
Objective To investigate the salvage efficacy of tanshinoneⅡA on reperfusion injury in rats with acute myocardial infarction.Methods Thirty SD rats were randomly divided into sham operation group(the sham group),AMI control group(the control group)and tanshinoneⅡA intervention group(the TSN group)to establish blood stasis model.In the sham group,only thoracotomy was performed without ligation.In the control group and the TSN group,myocardial infarction reperfusion model was established.Echocardiography of each group was observed before modeling and four weeks after reperfusion,and hemodynamic results of each group were compared four weeks after reperfusion.Results Echocardiographic results showed that the left ventricular internal dimension in systole(LVIDs)and left ventricular internal dimension-diastole(LVIDd)in the control group were larger than those in the sham group(P<0.05),and the left ventricular ejection fraction and left ventricular short-axis shortening rate were lower than those in the sham group(P<0.05).Compared with the control group,LVIDs and LVIDd in the TSN group were improved(P<0.05),and LVEF%and FS%were improved(P<0.05).Hemodynamic results showed that HR increased,LVSP decreased and LVEDP increased in the control group compared with the sham operation group after four weeks of reperfusion(P<0.05).Compared with the control group,the TSN group increased LVSP and decreased LVEDP with statistically significant differences(P<0.05),but HR had no statistically significant difference(P>0.05).Conclusion TanshinoneⅡA improves cardiac function after acute myocardial infarction in blood stasis rats.
作者
林冬铭
陈超
陆明
陈菲
王审
周亚萍
黄抒伟
LIN Dongming;CHEN Chao;LU Ming;CHEN Fei;WANG Shen;ZHOU Yaping;HUANG Shuwei(Department of Cardiovascular Internal Medicine,the Second Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310005,China;Yunhe County Hospital of Traditional Chinese Medicine in Zhejiang Province,Yunhe 323600,China;Zhejiang Chinese Medical University,Hangzhou 310053,China)
出处
《中国现代医生》
2020年第18期32-36,共5页
China Modern Doctor
基金
浙江省中医药科技计划项目(2018ZB057)
浙江省中医药(中西医结合)重点学科建设计划项目(2017-XK-A14)。
关键词
丹参酮ⅡA
急性心肌梗死
无复流
心功能
大鼠
TanshinoneⅡA
Acute myocardial infarction
No relapse flow
Cardiac function
Rats
