摘要
目的:研究有氧运动和补充牡蛎肽对自发性高血压大鼠(SHR)血压及血清AngⅡ、ET-1、VEGF含量的干预作用和交互作用。方法:对SHR和WKY大鼠进行8周有氧运动和补充牡蛎肽,检测各组大鼠血压,血管紧张素Ⅱ(AngⅡ)、内皮素-1(ET-1)和血管内皮生长因子(VEGF)含量。结果:有氧运动联合补充牡蛎肽对降低SHR血清ET-1、VEGF含量无显著的交互作用(P>0.05),但对降低SHR血压和血清AngⅡ含量均有显著的交互作用(P<0.01)。有氧运动对降低SHR血压和血清VEGF含量均有显著的效应(P<0.01);补充牡蛎肽对降低SHR血压和血清AngⅡ、ET-1、VEGF含量均有显著的效应(P<0.01)。结论:在高血压的发展过程中,不进行干预血压在一定程度上会持续升高;有氧运动联合补充牡蛎肽通过降低SHR血清AngⅡ、ET-1和VEGF含量,保护血管内皮,从而降低血压;有氧运动联合补充牡蛎肽对降低SHR血压具有协同效应。
Objective:To study the intervention and interaction of aerobic exercise and oyster peptide supplementation on blood pressure and serum AngⅡ,ET-1 and VEGF levels in spontaneously hypertensive rats(SHR).Methods:SHR and WKY rats were subjected to aerobic exercise for 8 weeks and supplemented with oyster peptides.The blood pressure,angiotensinⅡ(AngⅡ),endothelin-1(ET-1)and vascular endothelial growth factor(VEGF)of each group were detected.Results:Aerobic exercise combined with oyster peptide supplementation had no significant interaction effect on reducing serum ET-1 and VEGF levels in SHR(P>0.05),but it had significant interaction effect on reducing SHR blood pressure and serum AngⅡcontent(P<0.01).Aerobic exercise has a significant effect on reducing SHR blood pressure and serum VEGF content(P<0.01);supplementation of the oyster peptide has a significant effect on reducing SHR blood pressure and serum AngⅡ,ET-1,VEGF content(P<0.01).Conclusion:In the development of hypertension,blood pressure will continue to increase to a certain extent without intervention;aerobic exercise combined with oyster peptide supplements protects vascular endothelium by reducing the content of SHR serum AngⅡ,ET-1 and VEGF,thereby reducing blood pressure;And aerobic exercise combined with oyster peptide supplementation has a synergistic effect on reducing SHR blood pressure.
作者
陶雅浩
金其贯
TAO Yahao;JIN Qiguan(Physical Education School of Yangzhou University,Y angzhou 225127,Jiangsu,China)
出处
《辽宁体育科技》
2020年第4期67-71,共5页
Liaoning Sport Science and Technology
基金
2016年度国家重点研发计划课题(项目编号:2016YFD0400603-02)。
