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调节性T细胞在肾移植中的研究进展

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摘要 同种异体肾移植是治疗终末期肾脏疾病的最有效方法之一。免疫抑制药物的应用显著降低了肾移植术后T细胞介导的排斥反应的发生率,明显提高了肾移植术后患者生存率和改善了生活质量,但肾移植术后的长期预后不能令人满意[1-2],排斥反应仍然是制约肾移植发展的瓶颈。最为理想的办法是诱导受者对移植肾的特异性免疫耐受,但首要的问题如何检测和持续监测受者排斥反应情况却未有可靠的特异性指标。
出处 《现代实用医学》 2020年第7期877-879,共3页 Modern Practical Medicine
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  • 1Khan MA,Moeez S,Akhtar S. T-regulatory cell-mediated immunetolerance as a potential immunotherapeutic strategy to facilitategraft survival[J]. Blood Transfus, 2013,11 (3): 357-363. 被引量:1
  • 2Sagoo P,Lombardi G, Lechler RI. Relevance of regulatory T cellpromotion of donor-specific tolerance in solid organ transplantation[J]. Front Immunol, 2012, 3: 184. 被引量:1
  • 3Fehr T, Sykes M. Clinical experience with mixed chimerism toinduce transplantation tolerance [ J ] . Transpl Int,2008,21(12): 1118-1135. 被引量:1
  • 4Mathew JM,Leventhal JH,Miller J. Microchimerism in promotinggraft acceptance in clinical transplantation[ J]. Curr Opin OrganTransplant, 2011, 16 (4): 345-352. 被引量:1
  • 5Scandling JD,Busque S,Shizuru JA, et al. Induced immunetolerance for kidney transplantation [ J]. N Engl J Med, 2011,365 (14) : 1359-1360. 被引量:1
  • 6Matsushita T, Horikawa M,Iwata Y,et al. Regulatory B cells(B10 cells) and regulatory T cells have independent roles incontrolling experimental autoimmune encephalomyelitis initiationand late-phase immunopathogenesis [ J ]. J Immunol, 2010,185(4): 2240-2252. 被引量:1
  • 7Chen JC, Kuo ML, Ou LS, et al. Characterization of toleranceinduction through prenatal marrow transplantation : the requirementfor a threshold level of chimerism to establish rather than maintainpostnatal skin tolerance [ J ]. Cell Transplant, 2010,19 (12):1609-1622. 被引量:1
  • 8Badell IR,Russell MC, Thompson PW, et al. LFA-1 -specifictherapy prolongs allograft survival in rhesus macaques [ J ]. J ClinInvest, 2010,120 (12) : 4520- 4531. 被引量:1
  • 9Sewgobind VD,Kho MM,van der Laan LJ, et al. The effect ofrabbit anti-thymocyte globulin induction therapy on regulatory Tcells in kidney transplant patients [ J ] . Nephrol Dial Transplant,2009 , 24 ( 5) : 1635-1644. 被引量:1
  • 10Verbinnen B, Van Gool SW, Ceuppens JL Blocking costimulatorypathways : prospects for inducing transplantation tolerance [ J ].Immunotherapy, 2010,2 (4): 497-509. 被引量:1

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