摘要
细胞色素P450(cytochrome P450,CYP)酶是广泛存在于微生物、动植物及人体中与膜结合的血红蛋白类酶,具有氧化、环氧化、羟化、去甲基化等多种生物催化活性。CYP酶在药物、类固醇、脂溶性维生素和许多其他类型化学物质的代谢中具有重要作用,其在异源物质的解毒、药物相互作用和内分泌功能等领域的研究是热点问题。本综述对CYP的结构、功能、临床应用与开发前景进行了概述,并对其最新的研究现状和发展前景进行探讨。
Cytochrome P450(CYP),membrane-bound hemoglobin enzymes,are widely present in microorganisms,animals,plants,and human.CYPs have a variety of biocatalytic activities such as oxidation,epoxidation hydroxylation,demethylation et al.Therefore,they play a key role in detoxification of biotin,cell metabolism and maintaining homeostasis.More importantly,the catalytic activity of CYPs is a hot issue in the fields of drug interaction and endocrine function.Furthermore,they are also widely utilized in the metabolism of drugs,carcinogens,steroids,fat-soluble vitamins and many other types of chemicals.This review provides a comprehensive overview of the structure,function,clinical application,and development prospects of CYPs.Besides,we aim to discuss the latest research and development prospects of CYPs.
作者
宋展
高鑫
吴冕
路福平
秦慧民
SONG Zhan;GAO Xin;WU Mian;LU Fu-Ping;QIN Hui-Min(Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education,Tianjin 300457,China;College of Biotechnology,Tianjin University of Science and Technology,Tianjin 300457,China;National Engineering Laboratory for Industrial Enzymes,Tianjin 300457,China)
出处
《微生物学通报》
CAS
CSCD
北大核心
2020年第7期2245-2254,共10页
Microbiology China
基金
国家自然科学基金(31771911)。
