摘要
衰老(Aging)是机体发育过程中一种自然、复杂、不可避免的生理现象。人体衰老会使大脑功能发生改变,引发认知障碍。目前对衰老引起的认知障碍机制研究并不透彻,因此本文拟从氧化应激、炎性衰老、突触可塑性和表观遗传修饰等方面进行探讨,为了解衰老相关认知障碍的机制和临床研究提供参考。
Aging is a natural,complex and inevitable physiological phenomenon in the development of the body.The aging of the human body will change the brain function and cause cognitive decline.The current research on the mechanism of cognitive decline caused by aging is not thorough.This paper intends to discuss aspects such as oxidative stress,inflamm-aging,synaptic plasticity,and epigenetic modification to provide a reference for understanding the mechanism and clinical research of aging-related cognitive decline.
作者
梅健
王艳丽
雷莹
张宣怡
崔媛媛
邱忠营
MEI Jian;WANG Yan-li;LEI Ying;ZHANG Xuan-yi;CUI Yuan-yuan;QIU Zhong-ying(Shaanxi Key Laboratory of Brain Disorders,School of Basic Medical Sciences,Xi'an Medical University,Xi'an 710021,Shaanxi,CHINA;Department of Stomatology,Xi'an Central Hospital,Xi'an 710003,Shaanxi,CHINA)
出处
《海南医学》
CAS
2020年第15期2014-2017,共4页
Hainan Medical Journal
基金
陕西省自然科学基础研究计划(编号:2018JQ8003)
西安医学院博士科研启动基金(编号:2017DOC20)
西安医学院创新创业项目(编号:2018DC-66)
西安医学院配套基金项目(编号:2017PT28、2018PT11)。
关键词
衰老
认知障碍
氧化应激
炎性衰老
突触可塑性
表观遗传修饰
Aging
Cognitive decline
Oxidative stress
Inflamm-aging
Synaptic plasticity
Epigenetic modification
