摘要
目的探讨呼出气一氧化氮(FeNO)在不同年龄哮喘及哮喘性支气管炎患儿中的应用价值。方法选择≥6岁患儿105例(其中哮喘81例,哮喘性支气管炎24例),<6岁患儿71例(其中哮喘43例,哮喘性支气管炎患儿28例),分别检测FeNO的值,比较不同年龄组哮喘与哮喘性支气管炎患儿之间FeNO值的差别;同时用受试者工作特征曲线(ROC)界定出不同年龄组在患儿诊断哮喘的FeNO的最佳界值,比较不同年龄组FeNO切点值的敏感度及特异度差别。结果≥6岁患儿中,哮喘组FeNO值为(40.96±3.16)×10^-9 mol/L,哮喘性支气管炎组为(16.58±1.82)×10^-9 mol/L,两组差别有统计学意义(P<0.05);<6岁患儿中,哮喘组FeNO值为(26.33±3.43)×10^-9 mol/L,哮喘性支气管炎组为(13.89±1.09)×10^-9 mol/L,差别有统计学意义(P<0.05)。以23.5×10^-9 mol/L为折点鉴别诊断≥6岁哮喘及哮喘性支气管炎的灵敏度及特异度分别为75.3%及79.2%;以15.5×10^-9 mol/L为折点鉴别诊断<6岁哮喘及哮喘性支气管炎的灵敏度及特异度分别为63.8%及67.9%。结论在≥6岁及<6岁的喘息患儿中,FeNO值均有助于鉴别哮喘和哮喘性支气管炎所致的喘息,但FeNO值的测定对于≥6岁患儿哮喘的诊断具有更高的灵敏度及特异度,而对于<6岁的哮喘患儿,FeNO值对于哮喘诊断的灵敏度及特异度均较低。
Objective To explore the diagnostic value of fractional exhaled nitric oxide(FeNO)in asthma and asthmatic bronchitis children of different ages.Methods In this study,there were two age groups and 4 subgroups:105 patients older than 6-years old(older group),including 81 cases children of asthma and 24 cases of asthmatic bronchitis;71 patients younger than 6-years old(younger group),including 43 cases of asthma and 28 cases of asthmatic bronchitis.The level of FeNO in the 4 groups were measured and analyzed.The ROC curve was used to confirm Cut-off point to differentiate asthmatic bronchitis from patients with asthma in different ages.Compare the difference in sensitivity and specificity in older and younger groups.Result The level of FeNO in asthmatic group and asthmatic bronchitis group in older group were(40.96±3.16)×10^-9 mol/L and(16.58±1.82)×10^-9 mol/L respectively,the differences of FeNO were statistical significance(P<0.05),white the level of FeNO in asthmatic group and asthmatic bronchitis group in younger group were(26.33±3.43)×10^-9 mol/L and(13.89±1.09)×10^-9 mol/L,respectively,and the differences in FeNO were statistically significant(P<0.05).23.5×10^-9 mol/L was the best Cut-off point to differentiate asthma from asthmatic bronchitis in older group,the sensitivity was 75.3%and the specificity was 79.2%.13.5×10^-9 mol/L was the best cutoff point to differentiate asthma from asthmatic bronchitis in younger group,the sensitivity was 63.8%and the specificity was 67.9%.Conclusion FeNO can be a good biologic marker for differential diagnosis asthma from asthmatic bronchitis in recurrent wheezing children,but the sensitivity and specificity in older group were higher than that in the younger group.
作者
陈巧彬
郑晓颖
熊丽君
陈琅
缪长新
CHEN Qiaobin;ZHENG Xiaoying;XIONG Lijun;CHEN Lang;MIAO Changxin(Department of Pediatrics,Fujian Provincial Hospital,Fujian Provincial Clinical College of Fujian Medical University,Fuzhou 350001,China;Department of Pediatrics,Shouning Prefectural Hospital,Ningde 355500,China)
出处
《福建医科大学学报》
2020年第3期196-199,共4页
Journal of Fujian Medical University
