摘要
51岁女性患者,右侧颧骨外侧皮肤肿物伴瘙痒6个月,搔抓后肿物表面易出血。右侧颧部外侧皮肤见一直径约1 cm的类圆形微隆起的红褐色斑块,边界清晰,表面粗糙覆有雾状透明细鳞屑,可见毛细血管扩张和针尖大小新鲜出血点,压之褪色。组织病理示:皮损与两侧正常上皮分界清晰,表皮角化不全,皮突融合延长,棘层规则肥厚,细胞富含糖原、细胞质呈透明状,皮突与真皮交界处大量淋巴细胞及散在浆细胞、嗜酸粒细胞浸润。棘层细胞胞质PAS染色阳性,人乳头瘤病毒(HPV)免疫组化阴性。诊断:透明细胞棘皮瘤。完整切除术后随访1年未见复发。该例未发现恶性证据,仍考虑为良性表皮肿瘤。
A 51-year-old female presented with a 1 cm×1 cm red-brown,dome-shaped,solitary,slightly scaly and pruritic plaque on the right face for 6 months.which was easy to hemorrhage after scratching.Histopathologic examination showed sharply demarcated acanthosis composed of clear cells,which had transparent cytoplasm and normal nuclei.The PAS staining of the clear cells was positive,and the immunohistochemical staining of HPV was negative.This case is not similar to the other 3 cases reported previously as atypical or malignant clear cell acanthoma.The authors believe that these tumors are benign epidermic tumors.There was no recurrence during the first year of follow up.
作者
黄靖凯
薛如君
叶瑞贤
吕艳思
熊绮颖
刘焕颜
张三泉
梁景耀
张锡宝
HUANG Jing-kai;XUE Ru-jun;YE Rui-xian(Department of Dermatology,Guangzhou Institute of Dermatology&Institute of Dermatology,Guangzhou Medical University,Guangzhou 510095,China)
出处
《实用皮肤病学杂志》
2020年第3期188-190,共3页
Journal of Practical Dermatology
基金
国家自然科学基金(81872216)
2018年北京协和医学院研究生教育教学改革项目(10023201801701)。
