摘要
目的评价血浆同型半胱氨酸(Hcy)在急性心力衰竭(AHF)患者中的预后价值。方法本研究以2018年1月~2019年2月在安徽医科大学附属巢湖医院住院的AHF患者或心功能Ⅳ级的患者65例为心衰组,选取同期住院的65例无心衰患者为对照组。以上患者入院时均行血浆Hcy水平检测及心脏超声心动图检查,并随访6个月。结果心衰组患者血浆Hcy水平明显高于对照组,且血浆Hcy水平与左室舒张末内径(LVEDD)呈显著正相关,与左室射血分数(LVEF)、短轴缩短率(FS)呈负相关。本研究中,心衰组中患者死亡为5例,另34例6个月内再次入院,其中7例因心血管事件再入院;26例心功能控制满意,无不良事件发生。其中6个月内再入院或发生死亡患者的Hcy水平明显高于无不良事件发生的患者,差别具有统计学意义。结论血浆Hcy水平对急性心力衰竭患者有较好的预后价值,Hcy水平与临床及超声心动图资料、心衰严重程度及不良结局密切相关。
Objective To evaluate the prognostic value of plasma homocysteine(Hcy)in patient with acute heart failure(AHF).Methods From January 2018 to February 2019,65 hospitalized patients with AHF or cardiac function capacityⅣin Chaohu affiliated hospital of Anhui medical universty were selected as heart failure(HF)group,65 patients without HF as control group at the same time.The above patients underwent plasma Hcy detection and echocardiography when they were admitted and were followed up for 6 months.Results Hcy plasma levels were significantly higher in AHF group than in control group.Hcy plasma levels were significantly positively associated with left ventricular end-diastolic diameter(LVEDD),negatively with left ventricular ejection fraction(LVEF)and short axis shortening rate(FS).In this study,5 patients died and other 34 were readmitted within 6 months.7 of which were readmitted due to cardiovascular events.26 cases had satisfactory cardiovascular function controlled and no adverse events.Hcy levels were significantly higher in patients readmitted or died within 6 months than in patients without adverse events.Conclusion Hcy Plasma levels have good prognostic value for patients with AHF.Hcy is closely related to clinical and echocardiographic data,severity of HF and adverse outcomes.
作者
马洁
孙明
钱广兵
MA Jie;SUN Ming;QIAN Guang-bing(The Chaohu Affiliated Hospital of Anhui Medical Universty,Chaohu 238000)
出处
《临床输血与检验》
CAS
2020年第4期440-443,共4页
Journal of Clinical Transfusion and Laboratory Medicine
