摘要
目的探讨中国人群睡眠时间与癌症发病风险的关系,为癌症的预防控制提供科学依据。方法检索万方数据知识服务平台、中国知网数据库、维普数据库、PubMed数据库、Embase数据库和Web of Sciences数据库,并辅以文献追溯法收集各数据库建库至2018年9月30日国内外公开发表的有关中国人群睡眠时间与癌症发病风险关系的相关文献;应用Stata 12.0软件对纳入的文献进行meta分析。结果最终纳入7篇文献(中文文献3篇,英文文献4篇),累计癌症病例3104例。meta分析结果显示,与参照组相比,未发现睡眠时间过短组和过长组与癌症发病有关(均P>0.05);亚组分析结果显示,仅发现病例对照研究中睡眠时间过长可增加中国人群的癌症发病风险(OR=1.31,95%CI=1.11~1.55,P<0.01);敏感性分析和发表偏倚检验结果显示,本次meta分析纳入的文献不存在发表偏倚,结果较为稳定。结论基于病例对照研究证据,睡眠时间过长会增加中国人群癌症的发病风险。
Objective To explore the association between sleep duration and cancer incidence in Chinese population and to provide evidences for cancer prevention and control.Methods We carried out a systematic search,as well as backward citation tracking,for literatures published up to September 30 th 2018 on sleep duration and cancer incidence risk in Chinese population through Wanfang Data Knowledge Service Platform,China National Knowledge Infrastructure(CNKI),the Chinese Scientific Journal Database(VIP),PubMed,Embase and Web of Sciences for a meta-analysis with Stata 12.0 software.Results Totally 7 studies(4 published in English and 3 in Chinese)were included,and 3104 cancer cases were pooled into the meta-analysis.The meta-analysis revealed that compared to that in the controls,increased cancer risk was not observed in the cases with both short or long sleep duration(P>0.05).While,subgroup analysis demonstrated that long sleep duration was associated with cancer risk in case-control studies(odds ratio[OR]=1.31;95 confidence interval[95%CI]:1.11–1.55).Sensitivity analysis and publication bias test indicated that there was no publication bias for included cohort studies and case-control studies and the results of the meta-analysis were stable.Conclusion Based on evidences from case-control studies,long sleep duration could increase cancer risk in Chinese population.
作者
陈玉恒
王亚龙
冯小双
吕章艳
谭锋维
代敏
CHEN Yu-heng;WANG Ya-long;FENG Xiao-shuang(Cancer Foundation of China,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China;不详)
出处
《中国公共卫生》
CAS
CSCD
北大核心
2020年第7期1104-1108,共5页
Chinese Journal of Public Health
基金
国家重点研发计划(2018YFC1315000
2017YFC0907900)
中央保健专项资金(W2017BJ39)
北京市科技计划(D171100002617001)
北京市优秀人才培养资助–青年拔尖团队项目(2017000021223TD05)
中国医学科学院医学与健康科技创新工程项目(2017–I2M–1–006)。
关键词
癌症
发病风险
睡眠时间
关系
中国人群
META分析
cancer
incidence risk
sleep duration
association
Chinese population
meta-analysis
