摘要
目的探讨复方大黄软膏外敷对晚期腹部恶性肿瘤腹胀患者免疫及血清糖类抗原125(CA125)、糖类抗原724(CA724)、癌胚抗原(CEA)水平的影响。方法选取2017年7月—2019年7月期间晚期腹部恶性肿瘤合并腹胀症状的患者68例,按照数字表法随机分为治疗组和对照组各34例。对照组给予常规肿瘤治疗,治疗组在对照组基础上加用复方大黄软膏外敷,两组均治疗15 d。比较两组临床疗效,治疗前后血清CA125、CA724、CEA及免疫功能(CD4^+、CD8^+、CD4^+/CD8^+)水平变化,记录主次症消失时间,观察并记录两组不良反应发生情况。结果治疗后治疗组总有效率91.18%(31/34)显著高于对照组76.47%(26/34)(P<0.05)。治疗组腹痛、腹胀、大便不调、呕吐各主次症消失时间均显著短于对照组(P<0.05)。与治疗前比较,治疗后两组血清CA125、CA724、CEA水平均降低,且治疗组显著低于对照组(P<0.05)。与治疗前比,治疗后两组CD8^+水平均降低(P<0.05),且治疗组显著低于对照组(P<0.05);两组CD4^+及CD4^+/CD8^+水平均升高(P<0.05),且治疗组显著高于对照组(P<0.05)。治疗组不良反应总发生率8.82%显著低于对照组23.53%(P<0.05)。结论复方大黄软膏外敷可抑制晚期腹部恶性肿瘤腹胀患者肿瘤因子表达,提高免疫功能,加快症状消失所用时间,疗效显著,且安全性良好。
Objective To investigate the effect of compound rhubarb ointment external application on immunity and serum carbohydrate antigen 125(CA125),carbohydrate antigen 724(CA724)and carcinoembryonic antigen(CEA)levels in patients with advanced abdominal malignant tumor abdominal distension.Methods From July 2017 to July 2019,68 patients with advanced abdominal malignant tumors with bloating symptoms were randomly divided into a treatment group and a control group of 34 cases according to the digital table method.The control group was treated by routine oncology treatment,and the observation group was treated with compound rhubarb ointment on the basis of the control group.Both groups were treated for 15 days.The clinical efficacy of the two groups was compared,and the changes in serum CA125,CA724,CEAand immune function(CD4^+、CD8^+、CD4^+/CD8^+)levels before and after treatment were recorded,the disappearance time of primary and secondary symptoms was recorded,and the occurrence of adverse reactions in the two groups was observed and recorded.Results The total effective rate(91.18%)of the observation group was significantly higher than that of the control group(76.47%)(P<0.05).The disappearance time of primary and secondary symptoms of abdominal pain,abdominal distension,defecation and vomiting in the study group was significantly shorter than that in the control group(P<0.05).Compared with before treatment,serum CA125,CA724,CEAlevels in both groups were decreased after treatment,and the observation group was significantly lower than the control group.The levels of CD4^+and CD4^+/CD8^+in both groups were increased,which was significantly higher in the observation group than in the control group,the level of CD8^+was decreased in both groups and was significantly lower in the observation group than in the control group(P<0.05).The overall incidence of adverse reactions in the observation group(8.82%)was significantly lower than that in the control group(23.53%)(P<0.05).Conclusion Compound rhubarb ointment applied exter
作者
张彬
ZHANG Bin(Department of Oncology,Five Departments,Luzhou Hospital of Traditional Chinese Medicine,Luzhou Sichuan 646000)
出处
《世界中西医结合杂志》
2020年第7期1300-1303,共4页
World Journal of Integrated Traditional and Western Medicine
基金
2017年泸州市科技局科技计划项目
泸州市卫计委科研课题(2017-S-46)。
关键词
晚期腹部恶性肿瘤
腹胀
复方大黄软膏外敷
糖类抗原125
糖类抗原724
癌胚抗原
Advanced Abdominal Malignant Tumor
Abdominal Distension.Compound Rhubarb Ointment External Application
Carbohydrate Antigen 125
Carbohydrate Antigen 724
Carcinoembryonic Antigen
