摘要
Background Exosomes are bilayer lipid membranous vesicles with a diameter of 40-100 nm.They play an important role in signal transduction among cellular substances.Exosomes miR-206 and miR-122-5 have been found to play a regulatory role in cardiovascular diseases such as chronic heart failure,and therefore have gradually become the focus of various studies.The review has introduced the biological characteristics of the exosomal microRNAs,the association between exosomes miR-122-5 p,miR-206 and chronic heart failure,and briefly described the therapeutic prospects of these two exosomal miRNAs in the treatment of chronic heart failure.It may provide some new directions for the diagnosis and treatment of heart failure.
作者
FAN Lin-lin
ZHONG Yuan-yuan
Nomi Adnan
ZHANG Jin-guo
范琳琳;仲媛媛;Nomi Adnan;张金国(Jining Medical University,Jining 272067,Shandong,China;Jining Medical University,School of International Education,jining 272067,Shandong,China;The Second Department of Cardiology,Affiliated Hospital of Jining Medical University,Jining 272029,Shandong,China)
基金
supported by the Jining City Science and Technology Key Research and Development Program(No. 2018SMNS006)
the 2018 Shandong Province professional degree graduate case teaching project(No.SDYAL18100)
