摘要
系统性红斑狼疮(SLE)是典型的自身免疫疾病,其发病率、死亡率都较高.炎性因子和自身抗体的产生与SLE发病机制密切相关.研究发现,SLE患者的外周血中TCRαβ^+CD3^+CD4^-CD8^-T细胞(简称“双阴性”T细胞,DN-T细胞)数量明显增多,且与SLE的活动相关,其起源和功能尚不清楚.越来越多的研究认为DN-T细胞中环磷酸腺苷响应元件调节因子α(CREMα)的过表达和哺乳动物雷帕霉素靶蛋白(mTOR)的激活是SLE病理生理中的关键因素.本文主要介绍DN-T细胞的起源、功能特性及在SLE的致病作用,以寻求治疗SLE的新途径.
Systemic lupus erythematosus(SLE)is a typical autoimmune disease with high morbidity and mortality.The production of inflammatory factors and autoantibodies is closely related to the pathogenesis of SLE.It has been found that the number of TCRαβ^+CD3^+CD4^-CD8^-T cells(DN-T cells)in the peripheral blood of SLE patients is significantly increased and related to the activity of SLE,but its origin and function are still unclear and controversial.More and more studies suggest that the overexpression of cAMP responsion element modulator(CREM)αin DN-T cells and the activation of mammalian target of rapamycin(mTOR)are key factors in the pathophysiology of SLE.This article mainly introduces the origin,functional characteristics and the role of double negative T cells in SLE,in order to find a new way to treat the disease.
作者
杜孟茹(综述)
谢红浪(审校)
DU Mengru;XIE Honglang(National Clinical Research Center of Kidney Disease,Jinling Hospital,Jinling Clinical Medical College of Nanjing Medical University,Nanjing 210016,China)
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
北大核心
2020年第3期259-264,共6页
Chinese Journal of Nephrology,Dialysis & Transplantation
基金
江苏省临床医学中心(YXZXA2016003)。
