摘要
目的运用磁共振DTI(Diffusiontensor imaging)基于纤维束的空间统计分析技术(Tract Based Spatial Statistic,TBSS),对比分析伴有认知功能障碍的脑瘫患儿(Cerebral palsy,CP)与正常儿童(control group,CG)白质纤维束FA值的差异,为临床诊疗及干预提供精准影像学依据。方法选取53例30<DQ<70伴有认知功能障碍CP组患儿及50例正常对照CG组小儿,使用Philips Ingenia 3.0T磁共振成像仪,常规MRI序列及DTI功能成像序列检查,行DTI基于白质骨架的纤维束空间统计法分析。结果白质骨架图显示53例CP组患儿双侧额叶白质、右颞叶白质、右枕叶白质、右顶叶白质、双侧脑室体旁白质、双侧内囊前后肢较CG组的FA值明显减低(P值<0.05);随访13例CP组经6~12个月综合康复治疗后患儿的FA值在双侧内囊后肢区、右枕叶白质区、右侧内囊前肢区、右额叶白质区较康复前有所升高(P值<0.05)。结论DTI基于TBSS分析法将白质纤维束核心解剖结构可视化,揭示脑瘫患儿白质异常区域与认知功能损害之间的关系,为脑瘫患儿提供有价值的影像学指征及科学客观的理论依据。
Objective Use Diffusion tensor imaging(DTI)Based on trace-based Spatial Statistic(TBSS)to compare and analyze the differences of FA value between patients with Cerebral palsy(CP)and normal children(CG),so as to provide accurate imaging basis for clinical diagnosis and treatment and intervention.Methods 53 children with 30<DQ<70 and cognitive dysfunction in CP group and 50 cases of normal control CG group were selected.Routine MRI sequences and DTI functional imaging sequences were performed using Philips Ingenia3.0T magnetic resonance imager.Spatial statistical analysis of fiber bundles based on white matter skeleton was performed using DTI.Results The FA values of 53 CP group children with bilateral frontal white matter,right temporal white matter,right occipital white matter,right parietal white matter,lateral ventricle body white matter,bilateral internal capsule anterior and posterior limbs were significantly lower than those of CG group.After 6-12 months of comprehensive rehabilitation in the CP group,13 children were followed up.FA values of The brain areas in the posterior limb area of the bilateral internal capsule,the white matter area of the right occipital lobe,the forelimb area of the right internal capsule,and the white matter area of the right frontal lobe were higher than those before rehabilitation(P<0.05).Conclusion The core anatomical structure of white matter fiber bundle was visualized by DTI based on TBSS analysis to reveal the relationship between abnormal areas of white matter and cognitive impairment in children with cerebral palsy,providing valuable imaging indications and scientific and objective theoretical basis for children with cerebral palsy.
作者
郝明珠
张晓凡
王志伟
王芳
刘畅
张旭
朱凯
蔡静怡
HAO Ming-zhu;ZHANG Xiao-fan;WANG Zhi-wei(Department of Medical Imaging,Harbin Children's Hospital,Harbin 150000,Heilongjiang Province,China)
出处
《中国CT和MRI杂志》
2020年第9期1-3,10,共4页
Chinese Journal of CT and MRI
基金
黑龙江省科技厅自然科学基金资助面上项目(H2016003)。
关键词
小儿
脑瘫
认知功能障碍
扩散张量成像
纤维束示踪的空间统计学全脑分析法
Pediatric
Cerebral palsy
Cognitive Impairment
Diffusion Tensor Imaging(DTI)
Whole Brain Analysis Using Spatial Statistics for Fiber Tracer
