摘要
目的:探讨纳洛酮联合醒脑静对重度酒精中毒患者神经递质表达的影响和临床治疗效果。方法:选取笔者所在医院2018年10月-2019年12月收治的急性重度酒精中毒患者188例为研究对象,按照随机数字表法将患者分成研究组和对照组,每组94例。对照组给予醒脑静进行治疗,研究组给予纳洛酮联合醒脑静治疗。比较两组治疗后意识恢复时间、语言恢复时间和运动恢复时间和神经递质表达指标。结果:研究组意识恢复时间、语言恢复时间和运动恢复时间均早于对照组,差异有统计学意义(P<0.05)。治疗前,两组DA、5-HT、NE、E比较差异均无统计学意义(P>0.05);治疗后,研究组DA、5-HT、NE、E均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组β-EP、AVP、NO比较差异均无统计学意义(P>0.05);治疗后,研究组β-EP、AVP、NO均低于对照组,差异有统计学意义(P<0.05)。结论:采用纳洛酮联合醒脑静治疗重度酒精中毒的临床综合效果显著,患者恢复更快,能够更好地改善神经递质表达指标。
Objective:To investigate the influence of Naloxone combined with Xingnaojing on the neurotransmitters expression in patients with severe alcoholism and its clinical treatment effect.Method:A total of 188 patients with acute severe alcoholism admitted in our hospital from October 2018 to December 2019 were selected as the study objects.According to the random number table method,the patients were divided into the study group and the control group,with 94 cases in each group.The control group was treated with Xingnaojing,and the study group was treated with Naloxone combined with Xingnaojing.The consciousness recovery time,language recovery time,motor recovery time and neurotransmitters expression indicators were compared between the two groups after treatment.Result:The recovery time of consciousness,language and motor in the study group were earlier than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in DA,5-HT,NE and E between the two groups(P>0.05).After treatment,DA,5-HT,NE and E in the study group were all lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences inβ-EP,AVP,NO between the two groups(P>0.05).After treatment,β-EP,AVP,NO in the study group were all lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Naloxone combined with Xingnaojing in the treatment of severe alcoholism has a significant clinical comprehensive effect.Patients recover faster and can better improve neurotransmitters expression indicators.
作者
林久饶
陈胜荣
陈闽希
陈清军
LIN Jiurao;CHEN Shengrong;CHEN Minxi;CHEN Qingjun(Ningde Hospital Affiliated to Fujian Medical University,Ningde 352100,China;不详)
出处
《中外医学研究》
2020年第18期44-46,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
纳洛酮
醒脑静
重度酒精中毒
应用效果
神经递质
Naloxone
Xingnaojing
Severe alcoholism
Application effect
Neurotransmitters
