摘要
卵巢储备功能减退 (DOR) 包括生殖功能减退和内分泌功能减退,最终导致女性生育力下降。内质网是细胞内重要的细胞器,参与蛋白的合成折叠与分泌、脂质代谢、类固醇激素合成、Ca^2+储存等细胞内活动。细胞内外环境的变化,如氧化应激等皆有可能扰乱内质网稳态,导致内质网未折叠蛋白反应 (UPR)。初期UPR有助于维持机体细胞存活,但刺激强度过高或时间过长,则会导致细胞凋亡。越来越多的研究证实,内质网应激参与DOR发生的病理机制,与卵泡闭锁、卵巢纤维化增加、激素合成功能下降等过程密切相关。本文将综述DOR发生发展过程中的内质网应激机制及其研究进展。
Diminished ovarian reserve(DOR)is characterized by reduced reproductive capacity and endocrine disorders,causing poor fertility outcomes.Endoplasmic reticulum(ER)is an important organelle responsible for several cellular functions,including synthesis and folding of proteins,lipid metabolism,steroid hormone synthesis and Ca^2+storage.Various types of stress can disrupt ER homeostasis and induce ER stress,mainly unfolded protein response(UPR).At initial stage the UPR promotes cell survival,but along with excessive or prolonged stress it will lead to apoptosis.Recently more evidence demonstrates that ER stress is involved in the initiation of DOR and associated with follicle atresia,decreased hormone synthesis and ovarian fibrosis.This review will focus on the research progress of ER stress on DOR.
作者
梁秀茹
孟艳
Liang Xiuru;Meng Yan(Center of Clinical Reproductive Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2020年第6期521-525,共5页
Chinese Journal of Reproduction and Contraception
基金
江苏省自然科学基金(BK20161592)
默克雪兰诺中国生殖医学研究基金(MerckSerono-CREATE-2016023)。
关键词
内质网应激
卵巢储备功能减退
卵泡闭锁
类固醇激素
纤维化
Endoplasmic reticulum stress
Diminished ovarian reserve
Follicle atresia
Steroid hormone
Fibrosis
