摘要
目的研究放射性粒子植入术对老年乳腺癌患者近期疗效及预后的影响。方法选取80例老年乳腺癌患者,将2014年1月至2015年1月仅实施乳腺癌改良根治术治疗35例患者作为对照组,2015年2月至2016年1月实施乳腺癌改良根治术+放射性粒子植入术治疗的45例患者作为观察组。治疗结束后3~6个月,评估两组患者的近期疗效;手术前后,比较两组患者血清癌胚抗原(CEA)、糖类抗原153 (CA153)、糖类抗原152(CA152)水平;采用欧洲癌症研究与治疗组织开发的生命质量测定量表(EORTCQLQ-C30)比较两组患者的生活质量。比较两组患者术后1年复发率、术后3年总生存率(OS)。结果观察组患者手术治疗结束后临床总有效率为88.89%,高于对照组患者的68.57%,差异有统计学意义(P<0.05)。手术前,两组患者血清肿瘤标志物水平和EORTC QLQ-C30量表各维度评分比较,差异均无统计学意义(P> 0.05)。手术后,两组患者血清CEA、CA153、CA125水平均低于本组手术前,EORTCQLQ-C30量表各维度评分均高于本组手术前,且观察组患者血清CEA、CA153、CA125水平均低于对照组患者,EORTCQLQ-C30量表各维度评分均高于对照组患者,差异均有统计学意义(P<0.05)。观察组患者术后1年复发率为26.67%,低于对照组患者的51.43%;术后3年生存率为62.22%,高于对照组患者的34.28%,差异均有统计学意义(P<0.05)。结论老年乳腺癌患者在乳腺癌改良根治术基础上进行放射性粒子植入治疗,能有效提高近期疗效,降低血清肿瘤标志物水平,提高生活质量,预后较好。
Objective To study the short-term effect and prognosis of brachytherapy in elderly patients with breast cancer.Method A total of 80 elderly patients with breast cancer were included in the analysis,among them,35 cases treated only with modified radical mastectomy from January 2014 to January 2015 were enrolled into the control group,another 45 patients with breast cancer treated with modified radical mastectomy and radioactive seed implantation from February 2015 to January 2016 were included in study group of this research.The short-term efficacy in both groups were evaluated within 3~6 months after the end of treatment;the levels of serum carcinoembryonic antigen(CEA),carbohydrate antigen 153(CA153) and CA152 levels were detected before and after surgery,and compared between the two groups;the scores of European Organization for Research and Treatment of Cancer quality of life core questionnaire 30(EORTC QLQ-C30) were recorded to assess the quality of life of all patients.The incidence rate of postoperative complications within 1 year after surgery,and postoperative 3-year overall survival rate(OS) were statistically summarized and compared for the two groups.Result The short-term clinical response rate of the study group patients was 88.89%,which was higher than that of the control group at 68.57%(P<0.05).Before surgeries,the serum tumor marker levels and EORTC QLQ-C30 scores in the two groups were similar(P>0.05);while after surgery,the serum CEA,CA153,CA125 levels in both groups decreased notably,and EORTC QLQ-C30 scores of all dimensions were improved in all patients,besides,these changes were obviously more evident in study group patients than those in control group subjects(P<0.05).The 1-year recurrence rate in study group was 26.67%,which was lower than that in the control group at 51.43%,additionally,the 3-year survival rate was 62.22% in study group,and was significantly higher than the 34.28% observed in control group(P<0.05).Conclusion The brachytherapy on the basis of modified radical mastectomy can
作者
赵凌云
ZHAO Lingyun(Department of Geriatric Oncology,Kaifeng People’s Hospital,Kaifeng 475000,He’nan,China)
出处
《癌症进展》
2020年第13期1349-1353,共5页
Oncology Progress
