摘要
目的探讨舒痉通痹法对消渴痹证患者疗效及血清中IGF-1和MMP-9的影响。方法选取医院86例消渴痹证患者,随机分为两组,各43例,对照组采用依帕司他片150 mg+甲钴胺片1.5 mg口服;观察组在此基础上给与舒痉通痹法(中药熏洗+贴敷)治疗,每日1剂,持续治疗2周为1个疗程。比较两组患者的临床疗效、血胰岛素样生长因子-1(insulin-like-growth factor-1,IGF-1)、基质金属蛋白酶-9(Matrix metalloproteinase-9,MMP-9)及正中神经、尺神经神经传导速度,记录不良反应状况。结果对照组有效率81.40%(35/43)低于观察组95.35%(41/43),差异具有统计学意义(P<0.05)。两组患者治疗前血IGF-1、MMP-9及正中神经、尺神经传导速度比较,差异无统计学意义(P>0.05)。治疗后对照组和观察组血IGF-1为(69.92±14.51)mg/L、(84.57±16.10)mg/L,血MMP-9为(108.24±31.43)mg/L、(77.91±30.23)mg/L,运动神经的正中神经肌电为(45.62±4.59)、(48.87±4.60),运动神经的尺神经肌电为(43.33±3.41)、(46.29±3.58),感觉神经的正中神经肌电为(40.25±4.13)、(43.62±4.25),感觉神经尺神经肌电为(38.62±3.95)、(41.36±4.06),对照组和观察组上述指标比较,差异具有统计学意义(P<0.05)。结论舒痉通痹法对消渴痹证患者的疗效确切,可改善运动神经和感觉神经障碍,升高IGF-1和降低MMP-9水平,且患者可以耐受。
Objective To investigate the effect of relieving spasm and removing obstruction therapy in the treatment of patients with diabetic arthralgia and its influence on serum levels of IGF-1 and MMP-9.Methods Eighty-six patients with diabetic arthralgia were randomly divided into two groups,43 cases in each group.The control group was treated with epalrestat 150 mg+Mecobalamin 1.5 mg orally.The observation group was additionally treatedwith Relieving Spasm and removing obstruction method,one dose a day.Two groups were continuously treated for two weeks as a course of treatment.The clinical efficacy,serum insulin-like-growth factor-1(IGF-1),matrix metalloproteinase-9(MMP-9)and median and ulnar nerve conduction velocities were compared between the two groups,and the adverse reactions were recorded.Results The effective rate of the control group(81.40%,35/43)was lower thanthat of the observation group(95.35%,41/43)(P<0.05).There was no significant difference in serum IGF-1,MMP-9,median nerve or ulnar nerve conduction velocity between the two groups before treatment(P>0.05).After treatment,serum levels of IGF-1 in control group and observation group after treatment were(69.92±14.51)mg/L and(84.57±16.10)mg/L,respectively.The MMP-9 levels of control group and observation groupwere(108.24±31.43)mg/L and(77.91±30.23)mg/L,respectively.The electromyography levels of the median nerve of the motor nerve of control group and observation groupwere(45.62±4.59)and(48.87±4.60),respectively.The electromyography levels of the ulnar nerve of the motor nerve of control group and observation groupwere(43.33±3.41)and(46.29±3.58),respectively.The electromyography levels of the median nerve of the sensory nerve of control group and observation group were(40.25±4.13)and(43.62±4.25),respectively.The electromyography levels of the ulnar nerve of the sensory nerve of control group and observation groupwere(38.62±3.95)and(41.36±4.06),respectively.There were significant difference between the two groups(P<0.05).Conclusion Relieving spasm
作者
刘青
谢薇
甘露
金丽萍
肖孟云
LIU Qing;XIE Wei;GAN Lu;JIN Liping;XIAO Mengyun(The First Affiliated Hospital of Guizhou University College of Traditional Chinese Medicine,Guiyang 550000,Guizhou,China;Guizhou University of Traditional Chinese Medicine,Guiyang 550000,Guizhou,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第6期244-247,共4页
Chinese Archives of Traditional Chinese Medicine
基金
贵州省科学技术厅(黔科合LH字【2014】7348)。
关键词
舒痉通痹法
消渴痹证
IGF-1
MMP-9
relieving spasm and removing obstructionmethod
diabetic Bi syndrome
IGF-1
MMP-9
