摘要
目的探讨诊刮术联合炔诺酮对更年期功能失调性子宫出血患者子宫内膜厚度的影响。方法将85例更年期功能失调性子宫出血患者随机分为观察组42例与对照组43例。2组均行诊刮术,对照组在诊刮术基础上给予米非司酮,观察组在诊刮术基础上予以炔诺酮,比较2组治疗后雌激素水平、子宫内膜厚度及不良反应发生率。结果治疗后,观察组雌二醇(E 2)、孕酮(P)、促黄体生成素(LH)水平显著低于对照组(P<0.05);治疗后,观察组子宫内膜厚度显著小于对照组(P<0.05);2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论诊刮术联合炔诺酮能有效改善更年期功能失调性子宫出血患者雌激素水平,减少子宫内膜厚度。
Objective To investigate the effect of curettage combined with norethindrone on endometrial thickness in patients with menopausal dysfunctional uterine bleeding.Methods Totally 85 patients with menopausal dysfunctional uterine bleeding were randomly divided into observation group(n=42)and control group(n=43),all given curettage.Control group was treated with curettage and mifepristone,while observation group was treated with curettage and norethindrone.The estrogen level,endometrial thickness and the incidence of adverse reactions were compared between two groups.Results AfteRtreatment,the levels of estradiol(E 2),progesterone(P)and luteinizing hormone(LH)in the observation group were significantly loweRthan those in the control group(P<0.05).AfteRtreatment,the endometrial thickness of observation group was significantly smalleRthan that in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion FoRpatients with menopausal dysfunctional uterine bleeding,curettage combined with norethindrone can improve estrogen level and decrease endometrial thickness.
作者
艾志东
AI Zhidong(Department of Gynecology and Obstetrics,Le'an County People's Hospital,Fuzhou,Jiangxi344000)
出处
《实用临床医药杂志》
CAS
2020年第9期97-100,共4页
Journal of Clinical Medicine in Practice
