摘要
目的分析持续血液滤过治疗脓毒血症患者急性肾衰竭临床疗效。方法在2018年6月—2019年9月期间该院收治的脓毒血症并且具有急性肾衰竭患者中选择了符合研究的66例,给予患者两种不同的治疗方式,并且将患者按照随机分组的方式分成观察组和对照组,对照组通过静脉血液透析滤过治疗,观察组通过持续血液滤过治疗,对比两组患者的治疗效果、各项指标情况、治疗前后生化指标情况。结果观察组的治疗效果为96.97%,高于对照组的69.69%(χ2=7.759,P=0.005)。观察组在连续肾脏替代疗法治疗时间、住院时间、机械通气时间、住院治疗时间等指标情况分别为(5.4±3.5)、(17.3±6.7)、(15.5±4.6)、(27.2±6.7)d,均要优于对照组(5.6±3.8)、(17.2±6.3)、(15.2±4.2)、(26.8±6.2)d(t=0.222、0.062、0.277、0.252,P>0.05)。观察组的治疗前后肌酐、血尿素氮、β2-微球蛋白水平、排尿量、内毒素、C反应蛋白等生化指标分别为(385.3±123.5)μmol/L、(167.2±73.3)μmol/L、(20.6±10.4)mmol/L、(12.4±4.5)mmol/L、(6.1±1.3)μg/L、(3.2±1.4)μg/L、(325.7±85.5)mL/g、(1 659.4±148.8)mL/g、(49.7±14.2)pg/mL、(14.4±8.3)pg/mL、(2.6±1.3)mg/dL、(0.4±0.5)mg/dL,治疗后指标优于对照组,但差异不显著,只有β2-微球蛋白水平较对照组差异有统计学意义(P<0.05)。结论持续血液滤过治疗脓毒血症患者急性肾衰竭临床疗效显著,能够有效改善患者的临床症状。
Objective To analyze the clinical efficacy of continuous hemofiltration in the treatment of acute renal failure in patients with sepsis.Methods From June 2018 to September 2019,66 patients with sepsis and acute renal failure who were admitted to the hospital were selected in accordance with the study.The patients were given two different treatments,and the patients were randomized.The method of grouping was divided into observation group and control group.The control group was treated with venous hemodiafiltration.The observation group was treated with continuous hemofiltration.The treatment effect,various indicators,and biochemical indicators of the two groups were compared.Results The treatment effect in the observation group was 96.97%,which was higher than 69.69% in the control group(χ2=7.759,P=0.005).The observation group in terms of continuous renal replacement therapy treatment time,hospitalization time,mechanical ventilation time,and hospitalization treatment time were(5.4±3.5),(17.3±6.7),(15.5±4.6),and(27.2±6.7)d,which were better than the control group(5.6±3.8),(17.2±6.3),(15.2±4.2),(26.8±6.2)d(t=0.222,0.062,0.277,0.252,P>0.05).Biochemical indicators such as creatinine,blood urea nitrogen,β2-microglobulin level,urine output,endotoxin,and C-reactive protein in the observation group before and after treatment were(385.3±123.5)μmol/L,(167.2±73.3)μmol/L,(20.6±10.4)mmol/L,(12.4±4.5)mmol/L,(6.1±1.3)μg/L,(3.2±1.4)μg/L,(325.7±85.5)mL/g,(1 659.4±148.8)mL/g,(49.7±14.2)pg/mL,(14.4±8.3)pg/mL,(2.6±1.3)mg/dL,(0.4±0.5)mg/dL,the indexes after treatment were significantly better than those in the control group,but the difference was not statistically significant,only the β2-microglobulin lovel was statistically significant compered with the control group.Conclusion Continuous hemofiltration is effective in treating acute renal failure in patients with sepsis,and it can effectively improve the clinical symptoms of patients.
作者
罗洪才
LUO Hong-cai(Department of Critical Care Medicine,Zhaotong First People's Hospital,Zhaotong,Yunnan Province,657000 China)
出处
《世界复合医学》
2020年第5期122-124,共3页
World Journal of Complex Medicine
关键词
持续血液滤过
脓毒血症
急性肾衰竭
临床效果
Continuous hemofiltration
Sepsis
Acute renal failure
Clinical effect
