摘要
目的探讨前列地尔对慢性心力衰竭(CHF)的治疗效果及对心肌胶原容积分数(CVF)、羟脯氨酸(HYP)水平的影响。方法选取2016年3月至2017年4月在郑州市第七人民医院接受治疗的80例CHF病人为研究对象,并将其采用随机数字表法分为对照组和观察组,对照组给予利尿剂、血管紧张素转化酶抑制剂、β-受体阻滞剂、地高辛等常规抗心力衰竭药物治疗,观察组在此基础上给予前列地尔治疗。观察两组病人的治疗效果,采用酶联免疫吸附法检测超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、HYP水平,采用改良Masson三色法染色计算CVF,采用心脏超声显像仪检测左室每搏输出量(LVEF)、左房内径(LAD)、右房内径(RAD)。比较两组病人治疗前后心功能、CVF、HYP水平的差异,并分析其安全性。结果观察组显效23例(57.5%),明显优于对照组15例(37.5%)(P<0.05);两组病人治疗前心功能指标差异无统计学意义,治疗后,观察组LVEF[(59.45±5.23)%比(55.12±5.02)%]和每搏输出量(SV)[(68.34±3.25)m L比(61.69±3.05)mL]高于对照组,LAD[(33.12±3.25)mm比(36.88±2.27)mm]、左室内径(LVD)[(38.19±3.22)mm比(42.03±3.16)mm]和RAD[(36.65±4.12)mm比(45.76±3.52)mm]低于对照组;两组病人治疗前CVF、HYP水平差异无统计学意义,治疗后,观察组CVF[(2.53±0.52)比(3.82±0.68)]和HYP[(32.34±4.22)μg/mg比(40.16±4.78)μg/mg]水平均低于对照组;两组病人在治疗期间,均未出现明显的肝、肾功能损伤等不良反应,其中对照组出现2例血压过低,1例心动过缓;观察组出现1例血压过低,1例心动过缓,两组安全性比较,差异无统计学意义。结论在常规药物的基础上应用前列地尔对慢性心力衰竭病人有较好的治疗效果,可明显改善病人的CVF、HYP水平,具有良好的应用价值。
Objective To explore the therapeutic effect of alprostadil on chronic heart failure(CHF)and its influence on the levels of collagen volume fraction(CVF)and hydroxyproline(HYP).Methods Eighty CHF patients who received treatment in The Seventh People’s Hospital of Zhengzhou from March 2016 to April 2017 were selected as the research subjects.They were randomly assigned into control group and observation group.The control group was treated with diuretic,angiotensin converting enzyme inhibitor,beta blocker,digoxin and other conventional anti heart failure drugs,and the observation group was treated with prostadil additionally.The treatment effects of two groups of patients were observed.The levels of high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor alpha(TNF-alpha)and HYP were detected by enzyme linked immunosorbent assay.The CVF was calculated by improved Masson tricolor staining.The left ventricular ejection fraction(LVEF),the left atrial diameter(LAD),and the right atrial diameter(RAD)were detected by the echocardiography.A comparison was made of the differences in cardiac function,CVF and HYP between the two groups before and after treatment,and its safety was analyzed.Results The clinical efficacy of the observation group was significantly better than that of the control group(57.5% vs.37.5%,P<0.05);there was no significant difference in cardiac function between the two groups before treatment.After treatment,The LVEF and stroke volume(SV) of the observation group were higher than those of the control group[(59.45±5.23)% vs.(55.12±5.02)%,(68.34±3.25)m L vs.(61.69±3.05)m L ],while LAD,left ventricular diameter(LVD)and RAD of the observation group were lower than those of the control group[(33.12±3.25)mm vs.(36.88±2.27)mm,(38.19±3.22)mm vs.(42.03±3.16)mm,(36.65±4.12)mm vs.(45.76±3.52)mm,respectively].There were no difference in CVF and HYP between the two groups before treatment.After treatment,the CVF and HYP levels in the observation group were lower than those in the control group[(
作者
王磊
WANG Lei(Department of Cardiology,The Seventh People’s Hospital of Zhengzhou,Zhengzhou,Henan 450000,China)
出处
《安徽医药》
CAS
2020年第8期1635-1638,共4页
Anhui Medical and Pharmaceutical Journal
