摘要
探讨胎盘生长因子(PLGF)在不同孕周单次检测与动态检测结合高危因素对子痫前期(PE)的预测价值,选取2019年1月至12月期间在本院行产检并分娩的PE孕妇52例为研究对象(研究组),同期抽取在本院行产前检查并分娩的非PE孕妇113例进行对照(对照组),根据建卡的孕周不同,分别于孕12~15周、16~20周、>20周后进行了PLGF单次检测或动态检测,并进行了高危因素筛查。结果显示,妊娠期糖尿病、孕前体重指数≥24、年龄≥35岁、辅助生殖技术妊娠、高血压病史等高危因素研究组明显高于对照组(P<0.05);研究组PLGF检测异常率明显高于对照组(P<0.05),动态检测异常率高于孕12~15周及孕16~20周单次检测异常率(P<0.05)。表明不同孕周PLGF的动态检测联合高危因素筛查对PE有一定预测价值。
To investigate the predictive value of placental growth factor(PLGF)during pregnancy with single test and dynamic test combined with high-risk factors for pre-eclampsia.A total of 52 pre-eclampsia patients who underwent prenatal examination and delivered in our hospital from January 1,2019 to December 31,2019 were selected as the research subjects(study group).113 non-preeclampsia pregnant women who were examined and delivered in our hospital were compared(control group).The gestational weeks were different according to the card.They were pregnant for 12-15 weeks,16-20 weeks,and>20 weeks.Later,a single or dynamic detection of PLGF was performed,and a screening of high-risk factors for pre-eclampsia was performed.The results showed that gestational diabetes high-risk factors such as BMI≥24,age≥35 years,pregnancy assisted reproductive technology,and history of hypertension were significantly higher in the study group than in the control group(P<0.05).The abnormal rate of PLGF detection in the research group was significantly higher than that in the control group(P<0.05),and the abnormal detection rate in the dynamic group was higher than the single detection abnormal rate in 12-15 weeks of pregnancy and 16-20 weeks of pregnancy(P<0.05).It shows that the dynamic detection of PLGF at different gestational weeks combined with screening for high risk factors has certain predictive value for PE.
作者
吴鹏
陶婷
施芳
王湘东
孙中平
王佐
吴仕元
WU Peng;TAO Ting;SHI Fang;WANG Xiangdong;SUN Zhongping;WANG Zuo;WU Shiyuan(Hengyang Maternal and Child Health Care Hospital,Hengyang 421001, Hunan, China;Yueyang Maternal and Child Health Care Hospital, Yueyang 414000, Hunan, China)
出处
《中南医学科学杂志》
CAS
2020年第4期399-402,共4页
Medical Science Journal of Central South China
基金
岳阳市科技局2018年度基础研究计划专项资助项目.
关键词
胎盘生长因子
高危因素
子痫前期
预测
placental growth factor
high risk factors
pre-eclampsia
prediction
