摘要
在移植间充质干细胞的临床实验中,由于受区存在氧和营养供应不足以及炎症反应的问题,治疗效率通常较低。将干细胞聚集成三维微组织球体有望解决此问题。该综述阐明三维微组织制造技术和应用的相关问题,并重点关注进一步临床转化的研究进展。
The efficiency of transplanted mesenchymal stem cell is generally low due to lack of oxygen and nutrient supply in clinical trials.This problem can be improved by aggregating stem cells into three-dimensional microtissues.This article elucidated the problems associated with the fabrication and application of three-dimensional microtissues,with particular attention to the possibility of further transfering these findings into clinical application.
作者
许曼
马东洋
XU Man;MA Dongyang(Department of Oral and Maxillofacial Surgery,The 940th Hospital of Joint Logistics Support Force of PLA,Lanzhou 730050,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2020年第5期888-895,共8页
Chinese Journal of Cell Biology
基金
国家自然科学基金面上项目(批准号:81670969)
中央高校研究基金(批准号:lzubjky-2017-it46)资助的课题。
关键词
间充质干细胞
三维微组织
治疗效率
mesenchymal stem cell
three-dimensional microtissue
therapeutic efficiency
