摘要
检测趋化因子受体7(chemokine receptor 7,CXCR 7)在正常宫颈组织、CIN宫颈组织及宫颈鳞癌宫颈组织中的mRNA及蛋白水平的表达情况。采取江西省妇幼保健院2016年6月-2017年12月新鲜宫颈组织标本103例,应用Western blot与RT-PCR技术,检测CXCR 7蛋白及mRNA在18例正常宫颈组织、18例宫颈鳞状上皮内瘤变组织、35例Ⅰ期宫颈鳞癌组织及32例ⅡB、ⅢB期宫颈鳞癌组织中的表达情况,并分析CXCR 7与宫颈鳞癌临床病理特征,如患者年龄、肌层浸润、肿瘤大小、FIGO分期之间的关系。结果表明,CXCR 7可能参与了宫颈鳞癌的增殖、生长、分化、侵袭等恶性行为,在对宫颈鳞癌早发现、早治疗及预后方面的研究中,CXCR 7可能提供了新的思路。
We focused on the clinical significance of mRNA and protein expression of chemokine receptor 7 gene(chemokine receptor 7,CXCR 7)in normal cervical tissues,cervical tissues of cervical intraepithelial neoplasia(CIN)and cervical squamous cell in carcinoma of cervix tissue and their detection method in this paper.The Western blot and RT-PCR were used to detect expression of CXCR 7 for 103 cases of cervical tissue specimens in Maternal and Child Health Hospital of Jiangxi Province in June 2016-December 2017,which included 18 normal cervical tissue,8 cases of cervical squamous intraepithelial the neoplasia and 35 cases of cervical squamous cell I and 32ⅡB,ⅢB cervical squamous cell carcinoma.To analyze the clinical significance of the CXCR 7 expression,we investigated or observed clinic-pathological features such as age,myometrial invasion,tumor size and FIGO stage.The results showed that CXCR7 was possible to involve in cervical squamous cell proliferation,growth,differentiation,invasion and other malignant transformation process.The research provides a possible approach of the early detection of cervical squamous cell carcinoma for early diagnosis,treatment and prognosis.
作者
袁建晖
胡小青
YUAN Jian-hui;HU Xiao-qing(Oncology Department,Jiangxi Maternal and Child Health Hospital,Nanchang 330006,China;Central Lab of Jiangxi Maternal and Child Health Hospital,Nanchang 330006,China)
出处
《内蒙古师范大学学报（自然科学汉文版）》
CAS
2020年第4期291-297,共7页
Journal of Inner Mongolia Normal University(Natural Science Edition)
基金
江西省科技计划资助项目(20151BBG70102)。
关键词
宫颈鳞癌
CXCR
7
增殖
侵袭
cervical squamous cell carcinoma
CXCR 7
proliferation
invasion
