摘要
目的探讨中药联合地塞米松超声透入治疗虹膜睫状体炎的疗效及对患者血液流变学和免疫功能的影响。方法选取76例(85只眼)虹膜睫状体炎患者,随机分为观察组和对照组,各38例。对照组采用常规西医及地塞米松超声透入治疗,观察组在对照组基础上给予中药辨证施治。治疗结束后随访30 d。观察两组患者治疗后临床疗效,血液流变学指标[全血高切黏度、全血低切黏度、血浆黏度、纤维蛋白原、红细胞压积及红细胞聚集指数(ARBC)],免疫功能(血清免疫球蛋白IgG、IgA、IgM水平),并发症(结膜水肿、出血、瘢痕以及疼痛、眼心反射)及复发情况。结果观察组治疗后总有效率为85.71%,明显高于对照组的62.79%,差异有统计学意义(P<0.05)。观察组治疗后全血高切黏度、全血低切黏度、血浆黏度和纤维蛋白原均较治疗前及对照组治疗后降低,差异有统计学意义(P<0.05,P<0.01)。两组治疗后IgG、IgA、IgM水平均降低(P<0.05,P<0.01),且观察组IgA含量明显低于对照组(P<0.01)。治疗后观察组并发症发病率均低于对照组,差异有统计学意义(P<0.05,P<0.01)。随访30 d,观察组复发率为2.38%,明显低于对照组的16.28%,差异有统计学意义(P<0.05)。结论中药联合地塞米松超声透入治疗虹膜睫状体炎具有较好的临床疗效,可明显改善患者临床症状、血液黏度及免疫功能,且并发症发生率及复发率低,患者预后良好,值得临床推广应用。
Objective To investigate the effect of Chinese medicine combined with dexamethasone ultrasound penetration in the treatment of iridocyclitis and its effect on hemorheology and immune function.Methods 76 cases(85 eyes)with iridocyclitis were randomly divided into observation group and control group,38 cases in each.The control group was treated with conventional western medicine and dexamethasone ultrasound penetration,and the observation group was treated with traditional Chinese medicine(TCM)syndrome differentiation,followed up for 30 days after treatment.Observe the clinical efficacy of the two groups of patients after treatment,blood rheology[whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,fibrinogen,hematocrit and erythrocyte aggregation index(ARBC)],immune function(serum immunoglobulin Protein IgG,IgA,IgM levels),complications(conjunctival edema,bleeding,scarring and pain,eye-heart reflex)and recurrence.Results The total effective rate of 85.71%in observation group was higher than 62.79%in control group(P<0.05).After treatment,the whole blood viscosity,plasma viscosity and fibrinogen of the observation group were lower than those of the control group and the treatment group(P<0.05 or P<0.01).After treatment,IgG,IgA and IgM reduced in the 2 groups(P<0.05 or P<0.01),and the IgA content in the observation group was significantly lower than that in the control group(P<0.01).After treatment,conjunctival edema,bleeding,scar,pain and ophthalmocardial reflex were observed in the control group,and only a small amount of conjunctival edema and pain were observed in the observation group,and the incidence was lower than that in the control group(P<0.05 or P<0.01).The recurrence rate of the observation group was 2.38%,which was significantly lower than that 16.28%in the control group(P<0.05).Conclusion Chinese medicine combined with dexamethasone ultrasound penetration therapy for iridocylitisis effective,can obviously improve clinical symptoms,reduce blood viscosity and level of immuno
作者
曹蕾
沈青青
万琦
余宝刚
CAO Lei;SHENG Qing-qing;WAN Qi;YU Bao-gang(Department of ultrasound,zibo fifth people′s hospital,Zibo Shandong 255000;Department of Cardiovascular Medicine,The Third People′s Hospital of Xingtai,Xingtai Hebei 054000;Emergency Department,Tangshan Workers Hospital,Tangshan Hebei 063000)
出处
《世界中西医结合杂志》
2020年第6期1100-1103,共4页
World Journal of Integrated Traditional and Western Medicine
基金
河北省医学科学研究课题计划项目(20191676)。
关键词
虹膜睫状体炎
中药
地塞米松超声透入
血液流变学
免疫功能
Iridocyclitis
Traditional Chinese Medicine(TCM)
Ultrasonic Penetration of Dexamethasone
Nail Rugae
Immune Function
