摘要
目的探究姑息性化疗在晚期非小细胞肺癌中的疗效。方法选择2015年3月至2017年3月在我院治疗并随访完成的晚期非小细胞癌患者88例,根据患者家属治疗意见分为两组各44例,姑息性化疗组采用姑息性化疗治疗,常规治疗组采用常规支持治疗。评估患者近期、中期以及远期疗效。结果治疗后3个月姑息性化疗组第1秒用力呼气量(FEV1)、FEV1占预计值百分比(FEV1%)水平显著优于常规治疗组,血清癌胚抗原(CEA)、癌抗原19-9(CA19-9)、细胞角蛋白19的可溶性片段(CYFR21-1)水平显著低于常规治疗组(P<0.05),两组不良反应发生率比较,差异无统计学意义(P>0.05)。姑息性化疗治疗12个月后各项生活质量评分均显著高于常规治疗组(P<0.05)。姑息性化疗组患者存活率(59.10%)显著高于常规治疗组(34.82%),差异有统计学意义(P<0.05)。结论姑息性化疗能提升非小细胞肺癌患者生存质量,延长生存时间,值得在临床推广。
Objective To explore the curative effect of palliative chemotherapy for advanced non-small cell lung cancer.Methods A total of 88 patients with advanced non-small cell lung cancer treated in our hospital from March 2015 to March 2018 were divided into 2 groups according to the patient's condition,44 in each group.The palliative chemotherapy group was treated with palliative chemotherapy while the routine treatment group was given routine supportive treatment.The short-term,medium-term and long-term curative effect was evaluated.Results The forced expiratory volume in the first second(FEV1)and the percentage of FEV1 in the predicted value(FEV1%)in the palliative chemotherapy group after 3 months of treatment were significantly better than those in the routine treatment group.The serum carcinoembryonic antigen(CEA),cancer antigen 19-9(CA19-9)and cytokerantin-19-fragment(CYFRA21-1)levels were significantly lower than those in the routine treatment group(P<0.05).The incidence of adverse reactions in the palliative chemotherapy group during treatment was not significantly different from that in the routine treatment group(P>0.05).The quality of life scores of the palliative chemotherapy group after 12 months of treatment were significantly higher than those of the routine treatment group(P<0.05).The survival rate of the palliative chemotherapy group was significantly higher than that of the routine treatment group(P<0.05).Conclusion Palliative chemotherapy can improve the quality of life of patients with non-small cell lung cancer,and prolong their survival time.
作者
高燕
GAO Yan(Pidu District People's Hospital,Chengdu 611730,China)
出处
《实用医院临床杂志》
2020年第4期244-247,共4页
Practical Journal of Clinical Medicine
关键词
姑息性化疗
非小细胞肺癌
顺铂
Palliative chemotherapy
Non-small cell lung cancer
Cisplatin
