摘要
目的探讨甲基强的松龙联合环磷酰胺对系统性红斑狼疮患者炎性因子、易栓状态的影响。方法我院收治的86例系统性红斑狼疮患者,按治疗方法分为单一组和联合组各43例。单一组采用甲基强的松龙冲击治疗,联合组采用甲基强的松龙联合环磷酰胺治疗,两组均治疗6个月,比较两组临床治疗总有效率、炎症因子水平白介素(IL)-6、IL-8、IL-10和血栓相关指标凝血酶原时间(PT)、D-二聚体(D-D)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)。结果联合组临床治疗总有效率高于单一组(P<0.05)。治疗后,两组IL-6、IL-8、IL-10及PT、D-D、APTT、TT均较治疗前有降低,联合组降低幅度更大(P<0.05)。结论甲基强的松龙联合环磷酰胺较单一甲基强的松龙冲击疗法在系统性红斑狼疮的治疗中疗效更加显著,可以减轻炎性反应,减少血栓形成,改善易栓状态。
Objective To explore the effects of methylprednisolone combined with cyclophosphamide on inflammatory factors and thrombophilic state in patients with systemic lupus erythematosus(SLE).Methods Eighty-six patients with SLE admitted to our hospital were randomly divided into a single group and a combined group with 43 cases in each group.The single group was treated with methylprednisolone and the combined group was treated with methylprednisolone and cyclophosphamide for 6 months.The total effective rate,levels of inflammatory factors(IL-6,IL-8 and IL-10)and thrombosis-related indicators(PT,D-D,APTT,and TT)were compared between the two groups.Results The total effective rates of the combined group were higher than those in the single group(P<0.05).After treatment,the levels of IL-6,IL-8 and IL-10 as well as PT,D-D,APTT and TT levels in the two groups were significantly reduced,and the reductions in the combined group was more significant(P<0.05).Conclusion Methylprednisolone combined with cyclophosphamide is more effective than single methylprednisolone impulse therapy in the treatment of SLE.It can reduce the inflammatory reaction,reduce the thrombosis and improve the thrombophilic state.
作者
李冠
罗伟军
LI Guan;LUO Wei-jun(Department of Rheumatology and Immunology,Huizhou Hospital Affiliated to Guangzhou Medical University,Huizhou Third People's Hospital,Huizhou 516002,China)
出处
《实用医院临床杂志》
2020年第4期124-127,共4页
Practical Journal of Clinical Medicine
关键词
甲基强的松龙
环磷酰胺
系统性红斑狼疮
炎性因子
易栓状态
Methylprednisolone
Cyclophosphamide
Systemic lupus erythematosus
Inflammatory factors
Thrombophilic state
