摘要
目的探讨右美托咪定与酮咯酸氨丁三醇复合应用对重度烧伤切痂植皮患者全麻苏醒期应激激素水平的影响。方法从2018年8月—2020年1月阶段在医院治疗的重度烧伤切痂植皮患者中选取64例,以上对象随机分组,包括观察组(n=32)和对照组(n=32)。观察组患者麻醉中给予右美托咪定复合酮咯酸氨丁三醇,对照组患者则给予等量生理盐水。结果两组患者拔管前(T0)时的MAP、HR值比较差异不明显(P>0.05)。拔管时(T1)和拔管后5min(T2)时的MAP和HR值,对照组均高于观察组(P<0.05)。观察组患者的苏醒时间和拔管时间,均短于对照组(P<0.05)。观察组患者拔管后的醛固醇、肾上腺素、皮质醇、血糖水平,均低于对照组(P<0.05)。观察组患者的躁动、胃肠道反应、苏醒延迟等不良反应发生率低于对照组(P<0.05)。结论右美托咪定复合酮咯酸氨丁三醇可获得有效的麻醉深度,有利于维持患者麻醉期间的生理状态平稳,减少了术后麻醉苏醒时长及不良反应,有效控制机体应激反应水平,保证患者苏醒期的安全。
Objective To explore the effect of dexmedetomidine combined with ketorolac and tromethamine on the stress hormone level in patients with severe burn,escharectomy and skin grafting during the recovery period of general anesthesia.Methods From August 2018 to January 2020,64 patients divided into observation group(n=32)and control group(n=32).The observation group was anesthetized with dexmedetomidine and ketorolac,and the control group was anesthetized with normal saline.Results There was no significant difference in MAP and HR between the two groups before extubation(T0)(P>0.05).MAP and HR in the control group were significantly higher than those in the observation group(P<0.05).The recovery time and extubation time of the observation group were shorter than those of the control group(P<0.05).The levels of aldosterol,adrenaline,cortisol and blood glucose in the observation group were lower than those in the control group(P<0.05).The incidence of restlessness,gastrointestinal reaction and delayed recovery in the observation group was lower than that in the control group(P<0.05).Conclusion Dexmedetomidine combined with ketorolac tromethamine can obtain effective anesthesia depth,help to maintain patient's physiological balance,reduce recovery time and adverse reactions,and control stress response and protect patients'safety.
作者
王亢
王玲
WANG Kang;WANG Ling(Department of Anesthesiology,Xuzhou Renci Hospital,Xuzhou Jiangsu 221000,China)
出处
《中国卫生标准管理》
2020年第13期131-133,共3页
China Health Standard Management
关键词
右美托咪定
酮咯酸氨丁三醇
重度烧伤
切痂植皮
全麻苏醒期
应激激素
dexmedetomidine
ketorolac tromethamine
severe burn
escharectomy and skin grafting
recovery period of general anesthesia
stress hormone
