摘要
通过药物靶标鉴定,可以建立药物活性与细胞表型之间的联系,阐明药物的作用机理,还可以发现药物的脱靶效应和耐药性机制,发现治疗药物的新靶点,并在药物开发的早期阶段预测可能存在的毒性,降低药物研发失败的风险。目前虽然科学技术取得了飞速发展,但是鉴定药物靶标依然是一件令人生畏的工作。本文对近10年来药物靶标鉴定方面的研究进展,特别是无化学标记的新技术进行了评述。
Drug target identification can help establish the association between drug activity and phenotypes,elucidate the mechanism of action,discover off-target effects and drug resistance mechanisms,discover new targets for therapeutic drugs,and predict possible side effects and toxicity at an early stage of drug discovery,thereby reducing the risk of failure in drug development.Although rapid progress has been made in scientific discoveries and technological advancements,the identification of drug targets is still a daunting task.Herein,the research progress in drug target identification during the past decade,especially novel technologies without chemical labeling,have been reviewed.
作者
宫莉
康经武
GONG Li;KANG Jingwu(State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;University of Chinese Academy of Sciences, Beijing 100049, China)
出处
《色谱》
CAS
CSCD
北大核心
2020年第8期877-879,共3页
Chinese Journal of Chromatography
基金
国家自然科学基金(21775158,21375140)
中国科学院战略先导B(XDB20020200)。
关键词
药物靶标鉴定
化学蛋白质组学
综述
drug target identification
chemical proteomics
review
