摘要
目的探讨健康管理对正常高值血压患者的血压及血管内皮依赖性舒张功能(EDD)的影响。方法选择在四川省人民医院体检中心进行体检的正常高值血压患者300例(参考组),运用血管内皮功能检测仪检测肱动脉血流介导的舒张功能(FMD)并实施一年的健康管理干预(研究组),计量资料干预前后参数比较采用配对t检验,比较两组间生活方式、BMI、腰围、收缩压、舒张压和FMD等的差异。结果与参照组相比,坚持随访一年后的278例研究组的生活方式明显改善,高盐、高脂饮食人数、吸烟和饮酒人数、BMI及腰围均显著降低,规律运动人数增加,差异有统计学意义(P<0.05)。研究组的收缩压和舒张压均较参照组明显降低[分别为(131.97±9.84)mmHg vs.(118.13±6.86)mmHg,P=0.04;(87.55±6.92)mmHg vs.(78.30±5.41)mmHg,P=0.01)],而研究组的FMD值较参照组明显升高[(11.54±3.17)%vs.(6.49±2.28)%,P=0.02]。结论健康管理能改善正常高值血压患者的不良生活方式,降低其血压和提高FMD值,起到保护血管内皮依赖性舒张功能的作用。
Objective To investigate the effect of health management on blood pressure and endothelium-dependent diastolic function(EDD)in patients with normal high blood pressure.Methods 300 patients with normal high blood pressure(reference group)who had undergone physical examination in the physical examination center of sichuanprovincial people s hospital were selected.The blood vessel-mediated diastolic function(FMD)of the brachial artery was detected using a vascular endothelial function tester and implement a one-year health management intervention(study group).The comparison of parameters before and after intervention was conducted by using a paired t test.The differences in lifestyle,BMI,waist circumference,systolic blood pressure,diastolic blood pressure and FMD between two groups were compared.Results Compared with the reference group,the lifestyles of 278 study groups who were followed up for one year were significantly improved.The number of high-salt,high-fat diets,smoking and drinking,BMI and waist circumference were significantly reduced,and the number of regular exercises increased with significance difference(P<0.05).The systolic and diastolic blood pressures of the study group were significantly lower than those of the reference group[respectively,(131.97±9.84)mmHg vs.(118.13±6.86)mmHg,P=0.04,(87.55±6.92)mmHg vs.(78.30±5.41)mmHg,P=0.01)],and the FMD value of the study group was significantly higher than that of the reference group[(11.54±3.17)%vs.(6.49±2.28)%,P=0.02].Conclusion Health management could improve the unhealthy lifestyle of patients with normal high blood pressure,reduce their blood pressure and increase FMD value,which play a role in protecting endothelium-dependent diastolic function.
作者
马孝湘
王林
杨雁华
帅平
许少贤
刘玉萍
Ma Xiaoxiang;Wang Lin;Yang Yanhua(Sichuan Academy of Medical Sciences·Health Checkup/Health Management Center of Sichuan Provincial People s Hospital,Chengdu,Sichuan 610072,China)
出处
《四川医学》
CAS
2020年第5期468-471,共4页
Sichuan Medical Journal
基金
四川省干部保健科研课题(编号:川干研2018-230)。
关键词
健康管理
正常高值血压
血管内皮依赖性舒张功能
health management
normal high blood pressure
vascular endothelium-dependent diastolic function
