摘要
目的:探讨不同治疗方案对男性慢性充血性心力衰竭(CHF)患者性激素水平的影响。方法:选取2017年12月~2019年5月我院收治的80例男性CHF患者作为研究对象,按照就诊顺序单双号分为对照组(n=40)和观察组(n=40)。对照组患者予以强心、利尿、扩血管以及吸氧等常规治疗,同时口服琥珀酸美托洛尔缓释片;观察组患者在对照组治疗的基础上予以重组人脑利钠肽。观察对比两组患者治疗前后血清雌二醇(E 2)、睾酮(T)水平。结果:观察组患者治疗后的血清E 2水平较治疗前降低,且低于对照组;观察组患者治疗后的血清T水平较治疗前升高,且高于对照组,均有统计学差异(P<0.05)。结论:重组人脑利钠肽联合美托洛尔治疗方案较单独使用美托洛尔方案更能提高男性CHF患者T水平,降低E 2水平,从而有利于缓解病情,具有较高临床价值。
Objective:To explore the effect of different treatment schemes on the level of sex hormone in male patients with chronic congestive heart failure(CHF).Methods:80 male CHF patients admitted to our hospital from December 2017 to May 2019 were included in the study.According to the admission order,patients were divided into control group(n=40)and observation group(n=40).Control group were treated with metoprolol succinate sustained-release tablets and conventional treatment scheme,such as cardiotonic measures,diuretic measures,vasodilator and oxygen inhalation,while the observation group were treated with additional recombinant human brain natriuretic peptide on that basis.The serum estradiol(E 2)and testosterone(T)levels before and after treatment were recorded and compared between groups.Results:Compare with the control group,the level of serum E 2 in the observation group was significantly lower,while the level of serum T was significantly higher(P<0.05).Conclusion:Compared with the treatment scheme with metoprolol alone,recombinant human brain natriuretic peptide combined with metoprolol can improve the testosterone level and reduce the estradiol level in men with chronic congestive heart failure,which is beneficial for alleviating the disease and has high clinical value.
作者
吕小宁
李涛
Lü Xiao-ning;LI Tao(Department of Cardiology,General Hospital of Yima Coal Industry Group Co.,Ltd,Sanmeixia 472300,China;Intensive Care Unit,Sanmenxia Hospital of the Yellow River,Sanmeixia 472300,China)
出处
《中国合理用药探索》
CAS
2020年第6期61-64,共4页
Chinese Journal of Rational Drug Use
关键词
重组人脑利钠肽
美托洛尔
慢性充血性心力衰竭
性激素
recombinant human brain natriuretic peptide
metoprolol
chronic congestive heart failure
sex hormone
