摘要
目的:探究聚乙二醇干扰素联合替比夫定序贯疗法对慢性乙肝患者肝功能及血清碱性纤维母细胞生长因子(BFGF)水平的影响。方法:将我院于2015年3月至2020年2月收治的166例慢性乙肝患者按随机数字表法分为观察组与对照组,每组患者均83例。对照组患者采取聚乙二醇干扰素治疗,观察组在对照组基础上联合替比夫定序贯疗法进行治疗。将两组生活质量、肝功能及血清BFGF水平展开对比。结果:两组患者经6个月的治疗后慢性肝病量表(CLDQ)评分均有所提升,且观察组改善大于对照组(P<0.05);两组患者肝功能指标及BFGF指标均有所下降,观察组下降幅度大于对照组(P<0.05)。结论:基于聚乙二醇干扰素联合替比夫定序贯疗法能够提升慢性乙肝患者生活质量,改善临床症状,促进患者肝功能恢复,降低血清BFGF水平。
Objective:To investigate the effect of pegylated interferon combined with tebivudine sequential therapy on liver function and serum basic fibroblast growth factor(BFGF)level in patients with chronic hepatitis B.Methods:166 patients with chronic hepatitis B treated in our hospital from March 2015 to February 2020 were divided into observation group and control group according to the method of random number table,83 patients in each group.The control group was treated with pegylated interferon and the observation group was treated with tibivudine sequential therapy on the basis of the control group.Compare the quality of life,liver function and serum BFGF level of the two groups.Results:Two groups of patients the CLDQ scale scores were improved after 6 months of treatment,and the improvement in the observation group was greater than that in the control group(P<0.05);the liver function index and BFGF index of the two groups were decreased,and the decrease in the observation group was greater than that in the control group(P<0.05).Conclusion:Polyethylene glycol interferon combined with tebivudine sequential therapy can improve the quality of life of patients with chronic hepatitis B,improve clinical symptoms,promote the recovery of liver function and reduce serum BFGF level.
作者
佳莉娟
方亚琼
JIA Li-Juan;FANG Ya-qiong(Infection Department,First Affiliated Hospital of Henan University of Science and Technology,Luoyang Henan 471000,China)
出处
《药品评价》
CAS
2020年第7期17-19,共3页
Drug Evaluation
